The incidence of inflammatory bowel disease (IBD) is rapidly rising throughout the world.
Although tremendous efforts have been made, limited therapeutics are available for IBD …

Nano-drug delivery systems (NDDS) for colon-targeted drug delivery are an active area of
research on local diseases affecting the colon, such as ulcerative colitis, Crohn’s disease, …

Transcription factor NRF2 is an important modifier of cellular responses to oxidative stress.
Although its cytoprotective effects are firmly established, recent evidence suggesting …

Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases, resulting in hypoxia in the cancer cells. …

Tumour necrosis factor α (TNF-α) binds to its receptor (TNFR1) and activates both death-
and inflammation/survival-related signalling pathways. The inflammation and survival-related …

Purpose Orally administered rutin reportedly ameliorates 2,4,6-trinitrobenzene sulfonic acid
(TNBS)-induced colitis of rats. We investigated the metabolic and pharmacological …

Nitric oxide (NO)-releasing nanoparticles (NPs) have emerged as a wound healing enhancer
and a novel antibacterial agent that can circumvent antibiotic resistance. However, the NO …

Caffeic acid phenethyl ester (CAPE) is an active component of propolis from honeybee. We
investigated potential molecular mechanisms underlying CAPE-mediated nuclear factor …

Importance of the field: Generally, a prodrug, a pharmacologically inactive derivative of an
active drug, is designed to modulate pharmacokinetic properties of the parent drug. Targeted …

In this study, we developed Lactobacillus rhamnosus GG (LGG)-encapsulating exfoliated
bentonite/alginate nanocomposite hydrogels for protecting probiotics by delaying gastric fluid …