Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases
of the dynamin family, mutation of which can cause neurological dysfunction. While fission…

Phosphorylation-dependent modulation of the vanilloid receptor TRPV1 is one of the key
mechanisms mediating the hyperalgesic effects of inflammatory mediators, such as …

Association of PKA with the AMPA receptor GluR1 subunit via the A kinase anchor protein
AKAP150 is crucial for GluR1 phosphorylation. Mutating the AKAP150 gene to specifically …

Ca 2+ is a key intermediary in a variety of signalling pathways and undergoes dynamic
changes in its cytoplasmic concentration due to release from stores within the endoplasmic …

Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the liver that
regulates nutrient and metabolic homeostasis. FGF21 production is increased in response to …

Transient receptor potential vanilloid receptor 1 (TRPV1)-mediated release of neuroactive
peptides and neurotransmitters from the peripheral and central terminals of primary sensory …

Ca v 1 (L-type) channels and calmodulin-dependent protein kinase II (CaMKII) are key
regulators of Ca 2+ signaling in neurons. CaMKII directly potentiates the activity of Ca v 1.2 and …

Mitochondrial fission and fusion impact numerous cellular functions and neurons are particularly
sensitive to perturbations in mitochondrial dynamics. Here we describe that male mice …

Injury, inflammation, and nerve damage initiate a wide variety of cellular and molecular
processes that culminate in hyperexcitation of sensory nerves, which underlies chronic …

The complement cascade is a key component of the innate immune system that is rapidly
recruited through a cascade of enzymatic reactions to enable the recognition and clearance of …