The liver plays several critical roles in the metabolic adaptation to fasting. We have shown
previously that the transcriptional coactivator peroxisome proliferator-activated receptor γ …

Bone marrow (BM) cells originally include alpha-fetoprotein (AFP)- and c-Met [a receptor for
hepatocyte growth factor (HGF)]-expressing cells. In vitro treatment of BM cells with HGF …

In immune cells, CD73 dephosphorylates and converts extracellular AMP into adenosine,
which binds the A2A adenosine receptor (A2AR). Blockade of this interaction, which induces …

New reliable biomarkers are needed to predict the response to immune checkpoint inhibitors
against programmed death-1 (PD-1) and its ligand (PD-L1), because PD-L1 expression on …

The drug metabolizing enzyme cytochrome P450 3A4 (CYP3A4) is thought to be involved in
the metabolism of nearly 50% of all the drugs currently prescribed. Alteration in the activity …

The eradication of Helicobacter pylori often leads to platelet recovery in patients with chronic
idiopathic thrombocytopenic purpura (cITP). Although this clinical observation suggests the …

The blends of poly(l-lactide) (PLLA) with poly(butylene succinate) (PBS) and poly(butylene
succinate-co-l-lactate) (PBSL) containing the lactate unit of ca. 3mol% were prepared by melt-…

We report a fabrication method for flexible and printable thermal sensors based on composites
of semicrystalline acrylate polymers and graphite with a high sensitivity of 20 mK and a …

Because of a critical shortage in suitable organs, many patients with terminal liver disease
die each year before liver transplantation can be performed. Transplantation of isolated …

Circadian control of physiology is mediated by local, tissue‐based clocks, synchronized to
each other and to solar time by signals from the suprachiasmatic nuclei (SCN), the master …