DNA interactions of bifunctional dinuclear platinum (II) antitumor agents
…, A Žákovská, J Kašpárková, Z Balcarová… - European Journal of …, 1997 - Wiley Online Library
Modifications of natural DNA in a cell‐free medium by dinuclear bisplatinum complexes with
equivalent coordination spheres, represented by the general formula [{trans‐PtCl(NH 3 ) 2 } …
equivalent coordination spheres, represented by the general formula [{trans‐PtCl(NH 3 ) 2 } …
DNA interactions of antitumor trans‐[PtCl2(NH3)(quinoline)]
A Žákovská, O Nováková, Z Balcarová… - European journal of …, 1998 - Wiley Online Library
Recent observations that several trans‐platinum complexes exhibit antitumor activity
including activity in cisplatin‐resistant tumor cells, violates the classical structure/activity …
including activity in cisplatin‐resistant tumor cells, violates the classical structure/activity …
DNA interactions of a novel platinum drug, cis-[PtCl (NH3) 2 (N7-Acyclovir)]+
Z Balcarová, J Kaspárková, A Zákovská… - Molecular …, 1998 - ASPET
We synthesized a novel platinum drug,cis-[PtCl(NH 3 ) 2 (N7-ACV)] + , in which ACV is the
antiviral drug acyclovir [a deoxyriboguanosine analogue, 9-(2-hydroxyethoxymethyl)guanine]. …
antiviral drug acyclovir [a deoxyriboguanosine analogue, 9-(2-hydroxyethoxymethyl)guanine]. …
Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes
TD McGregor, Z Balcarová, Y Qu, MC Tran… - Journal of inorganic …, 1999 - Elsevier
In this work, the B→Z transition of poly(dG-dC)·poly(dG-dC) and the B→A transition of poly(dG)·poly(dC)
and of calf thymus (CT) DNA fragments modified by antitumor bifunctional …
and of calf thymus (CT) DNA fragments modified by antitumor bifunctional …
DNA Modifications by Antitumortrans-[PtCl2 (E-Iminoether) 2]
…, A Žákovská, J Kašpárkova, Z Balcarová… - Molecular …, 1997 - ASPET
Recent findings that an analogue of clinically ineffective transplatin,trans-[PtCl 2 (E-iminoether)
2 ], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor …
2 ], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor …
[PDF][PDF] A study of drug binding to DNA by partial intercalation using a model phenazine derivative
V Kleinwächter, Z Balcarová, KE Reinert, H Triebel… - Gen Physiol …, 1986 - Citeseer
Spectrophotometry, thermal denaturation, sedimentation, and viscometric techniques were
used in a study of interaction of double helical DNA with an asymmetric phenazinium …
used in a study of interaction of double helical DNA with an asymmetric phenazinium …
Monofunctional adducts of platinum (II) produce in DNA a sequence-dependent local denaturation
V Brabec, V Boudny, Z Balcarova - Biochemistry, 1994 - ACS Publications
Revised Manuscript Received November 23, 1993® abstract: The effects on the conformation
of DNA produced by the monofunctional adducts of chloro-(diethylenetriamine) platinum (II…
of DNA produced by the monofunctional adducts of chloro-(diethylenetriamine) platinum (II…
[PDF][PDF] Cleavage by restriction enzymes of DNA modified with the antitumour drug cis-diamminedichloroplatinium (II)
Z Balcarova, J Mrazek, V Kleinwächter… - General Physiology and …, 1992 - gpb.sav.sk
The effect of binding of an antitumour drug cts-diamminedichloroplatinum (II)(cis-[PfNH3) 2
Cl2]) to DNA on cutting effectiveness of BamHI, EcoRI, and Sail restriction endonucleases …
Cl2]) to DNA on cutting effectiveness of BamHI, EcoRI, and Sail restriction endonucleases …
Interaction of phenosafranine with nucleic acids and model polyphosphates: II. Characterisation of phenosafranine binding to DNA
Z Balcarová, V Kleinwächter, J Koudelka, G Löber… - Biophysical …, 1978 - Elsevier
The binding of phenosafranine (PS) to DNA was studied by a combination of spectroscopic
methods (absorption and fluorescence) together with hydrodynamic measurements (…
methods (absorption and fluorescence) together with hydrodynamic measurements (…
Reinterpretation of fluorescence of terbium ion-DNA complexes
Z Balcarová, V Brabec - Biophysical chemistry, 1989 - Elsevier
Terbium (T 3+ ) fluorescence was used to investigate local non-denaturation perturbations of
double-helical DNA structure induced in this nucleic acid by various physical and chemical …
double-helical DNA structure induced in this nucleic acid by various physical and chemical …