Cholinergic switching within neocortical inhibitory networks
Z Xiang, JR Huguenard, DA Prince - Science, 1998 - science.org
Differential actions of acetylcholine on the excitability of two subtypes of interneurons in
layer V of the rat visual cortex were examined. Acetylcholine excited low-threshold spike (LTS) …
layer V of the rat visual cortex were examined. Acetylcholine excited low-threshold spike (LTS) …
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats
Recent studies suggest that subtype-selective activators of M 1 /M 4 muscarinic acetylcholine
receptors (mAChRs) may offer a novel approach for the treatment of psychotic symptoms …
receptors (mAChRs) may offer a novel approach for the treatment of psychotic symptoms …
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in …
…, SB Jadhav, UN Menon, Z Xiang… - Journal of …, 2009 - Soc Neuroscience
M 1 muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment
of disorders involving impaired cognitive function. However, a major limitation to testing …
of disorders involving impaired cognitive function. However, a major limitation to testing …
[HTML][HTML] mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning
…, R Williams, AN Telk, NL Watson, Z Xiang… - …, 2009 - nature.com
Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor
subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms …
subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms …
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4
…, KA Johnson, CD Weaver, CK Jones, Z Xiang… - Molecular …, 2008 - ASPET
Parkinson's disease (PD) is caused by the death of dopamine neurons in the basal ganglia
and results in motor symptoms such as tremor and bradykinesia. Activation of metabotropic …
and results in motor symptoms such as tremor and bradykinesia. Activation of metabotropic …
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission
JK Shirey, Z Xiang, D Orton, AE Brady… - Nature chemical …, 2008 - nature.com
Muscarinic acetylcholine receptors (mAChRs) provide viable targets for the treatment of
multiple central nervous system disorders. We have used cheminformatics and medicinal …
multiple central nervous system disorders. We have used cheminformatics and medicinal …
A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis
MA Benneyworth, Z Xiang, RL Smith, EE Garcia… - Molecular …, 2007 - ASPET
Recent clinical studies reveal that selective agonists of group II metabotropic glutamate (mGlu)
receptors have robust efficacy in treating positive and negative symptoms in patients with …
receptors have robust efficacy in treating positive and negative symptoms in patients with …
[PDF][PDF] Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents
Schizophrenia is associated with disruptions in N-methyl-D-aspartate glutamate receptor
subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate …
subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate …
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning
DJ Sheffler, R Williams, TM Bridges, Z Xiang… - Molecular …, 2009 - ASPET
Previous studies suggest that selective antagonists of specific subtypes of muscarinic
acetylcholine receptors (mAChRs) may provide a novel approach for the treatment of certain …
acetylcholine receptors (mAChRs) may provide a novel approach for the treatment of certain …
[PDF][PDF] Antipsychotic-like effects of M4 positive allosteric modulators are mediated by CB2 receptor-dependent inhibition of dopamine release
…, LJ Marnett, CM Niswender, CK Jones, Z Xiang… - Neuron, 2016 - cell.com
Muscarinic receptors represent a promising therapeutic target for schizophrenia, but the
mechanisms underlying the antipsychotic efficacy of muscarinic modulators are not well …
mechanisms underlying the antipsychotic efficacy of muscarinic modulators are not well …