In previous minireviews in this journal, we discussed work on induction of tetrahydrobiopterin
biosynthesis by cytokines and its significance for nitric oxide (NO) production of intact cells …

The dissociation of cytochrome c oxidase-nitric oxide complexes was studied by optical
spectroscopy at cryogenic temperatures (15 degrees K). With the reduced cytochrome c oxidase-…

Nitric-oxide synthase (NOS), the enzyme responsible for mammalian NO generation, is no
cytochrome P450, but there are striking similarities between both enzymes. First and foremost, …

Ever since the discovery that (6R)-5,6,7,8-tetrahydro-L-biopterin (BH4) is a cofactor of NOS,
its function has been the object of intense research and occasional controversy. Only in the …

Peroxynitrite, the reaction product of nitric oxide (NO) and superoxide (O2) is assumed to
decompose upon protonation in a first order process via intramolecular rearrangement to NO 3 …

… In the presence of suboptimal concentrations of -arginine, Ca#+\calmodulin-activated
nNOS exhibits NADPH oxidase activity, resulting in formation of superoxide anions and H …

The decomposition ofS-nitrosoglutathione (GSNO) in the presence of Cu 2+ and glutathione
(GSH) was studied by stopped-flow/rapid-scan spectroscopy. Reduction of Cu 2+ by GSH …

To elucidate potential mechanisms of S-nitrosothiol formation in vivo, we studied nitrosation
of GSH and albumin by nitric oxide ( • NO), peroxynitrite, and • NO/O 2 • − . In the presence of …

Nitric oxide synthase (EC 1.14.13.39; NOS) converts L-arginine into NO and L-citrulline in a
two-step reaction with N ω -hydroxy-L-arginine (NOHLA) as an intermediate. The active site …

The reaction of reduced NO synthase (NOS) with molecular oxygen was studied at −30 C. In
the absence of substrate, the complex formed between ferrous NOS and O 2 was sufficiently …