Estrogen receptor pathways to AP-1

…, DA Agard, GL Greene, TS Scanlan, AK Shiau… - The Journal of steroid …, 2000 - Elsevier
Estrogen receptor (ER) binds to estrogen response elements in target genes and recruits a
coactivator complex of CBP-pl60 that mediates stimulation of transcription. ER also activates …

[HTML][HTML] The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

AK Shiau, D Barstad, PM Loria, L Cheng, PJ Kushner… - Cell, 1998 - cell.com
Ligand-dependent activation of transcription by nuclear receptors (NRs) is mediated by
interactions with coactivators. Receptor agonists promote coactivator binding, and antagonists …

The role of pro regions in protein folding

D Baker, AK Shiau, DA Agard - Current opinion in cell biology, 1993 - Elsevier
… Pro regions in protein folding Baker, Shiau and Agard … Pro regions in protein folding Baker,
Shiau and Agard 969 … D Baker, AK Shiau and DA Ag~rd, Howard Hughes Medical Institute …

Expression cloning of an ATP receptor from mouse neuroblastoma cells.

KD Lustig, AK Shiau, AJ Brake… - Proceedings of the …, 1993 - National Acad Sciences
Extracellular ATP activates cell-surface metabotropic and ionotropic nucleotide (P2) receptors
in vascular, neural, connective, and immune tissues. These P2 receptors mediate a wealth …

[HTML][HTML] Structural analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements

AK Shiau, SF Harris, DR Southworth, DA Agard - Cell, 2006 - cell.com
In eukaryotes, the ubiquitous and abundant members of the 90 kilodalton heat-shock protein
(hsp90) chaperone family facilitate the folding and conformational changes of a broad array …

[HTML][HTML] Comprehensive analysis of single cell ATAC-seq data with SnapATAC

…, J Lucero, X Wang, A Motamedi, AK Shiau… - Nature …, 2021 - nature.com
… In the approximate joint r-rank embedding space \({\tilde{\mathbf{U}}}\), we next create a k-nearest
neighbor (KNN) graph in which every cell is represented as a node and edges are …

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

AK Shiau, D Barstad, JT Radek, MJ Meyers… - Nature structural …, 2002 - nature.com
The R,R enantiomer of 5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol (THC) exerts
opposite effects on the transcriptional activity of the two estrogen receptor (ER) subtypes, …

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

…, BJ Mitchell, A Desai, TC Gahman, AK Shiau… - Science, 2015 - science.org
Centrioles are ancient organelles that build centrosomes, the major microtubule-organizing
centers of animal cells. Extra centrosomes are a common feature of cancer cells. To …

Structure of LRRK2 in Parkinson's disease and model for microtubule interaction

…, O Donosa, R Watanabe, J Böhning, AK Shiau… - Nature, 2020 - nature.com
Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial
Parkinson’s disease 1 and is also linked to its idiopathic form 2 . LRRK2 has been proposed to …

[PDF][PDF] The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site

SF Harris, AK Shiau, DA Agard - Structure, 2004 - cell.com
Hsp90 is a ubiquitous, well-conserved molecular chaperone involved in the folding and
stabilization of diverse proteins. Beyond its capacity for general protein folding, Hsp90 …