Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to …

Snakes possess many extreme morphological and physiological adaptations. Identification
of the molecular basis of these traits can provide novel understanding for vertebrate biology …

Identification of microsatellites, or simple sequence repeats (SSRs), can be a time-consuming
and costly investment requiring enrichment, cloning, and sequencing of candidate loci. …

Platelet activation is a complex balance of positive and negative signaling pathways. The
protein kinase C (PKC) family is a major regulator of platelet granule secretion, integrin …

Optimal integration of next‐generation sequencing into mainstream research requires re‐evaluation
of how problems can be reasonably overcome and what questions can be asked. …

Protein tyrosine phosphorylation is a ubiquitous signalling mechanism and is regulated by a
balance between the action of kinases and phosphatases. The SH2 domain-containing …

Adenosine 5′-diphosphate (ADP) plays a central role in regulating platelet function by the
activation of the G protein–coupled receptors P2Y 1 and P2Y 12 . Although it is well …

… /017 to AW Poole; CH/03/003 to SP Watson); the Medical Research Council (MRC-65282
to SP Watson); and the NIH (NIHLB HL56652 to SW Whiteheart). AW Poole is a Biotechnology …

Current understanding of how platelets localize coagulation to wound sites has come mainly
from studies of a subpopulation of activated platelets. In this review, we summarize data …

Background— Platelets are central to the process of hemostasis, rapidly aggregating at
sites of blood vessel injury and acting as coagulation nidus sites. On interaction with the …