[HTML][HTML] Platelet secretion: From haemostasis to wound healing and beyond
EM Golebiewska, AW Poole - Blood reviews, 2015 - Elsevier
Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to …
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to …
The Burmese python genome reveals the molecular basis for extreme adaptation in snakes
…, JM Castoe, SE Fox, AW Poole… - Proceedings of the …, 2013 - National Acad Sciences
Snakes possess many extreme morphological and physiological adaptations. Identification
of the molecular basis of these traits can provide novel understanding for vertebrate biology …
of the molecular basis of these traits can provide novel understanding for vertebrate biology …
[HTML][HTML] Rapid microsatellite identification from Illumina paired-end genomic sequencing in two birds and a snake
TA Castoe, AW Poole, APJ De Koning, KL Jones… - PloS one, 2012 - journals.plos.org
Identification of microsatellites, or simple sequence repeats (SSRs), can be a time-consuming
and costly investment requiring enrichment, cloning, and sequencing of candidate loci. …
and costly investment requiring enrichment, cloning, and sequencing of candidate loci. …
[HTML][HTML] Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation
MT Harper, AW Poole - Journal of Thrombosis and Haemostasis, 2010 - Elsevier
Platelet activation is a complex balance of positive and negative signaling pathways. The
protein kinase C (PKC) family is a major regulator of platelet granule secretion, integrin …
protein kinase C (PKC) family is a major regulator of platelet granule secretion, integrin …
Rapid identification of thousands of copperhead snake (Agkistrodon contortrix) microsatellite loci from modest amounts of 454 shotgun genome sequence
Optimal integration of next‐generation sequencing into mainstream research requires re‐evaluation
of how problems can be reasonably overcome and what questions can be asked. …
of how problems can be reasonably overcome and what questions can be asked. …
A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail
AW Poole, ML Jones - Cellular signalling, 2005 - Elsevier
Protein tyrosine phosphorylation is a ubiquitous signalling mechanism and is regulated by a
balance between the action of kinases and phosphatases. The SH2 domain-containing …
balance between the action of kinases and phosphatases. The SH2 domain-containing …
P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms
AR Hardy, PB Conley, J Luo, JL Benovic, AW Poole… - Blood, 2005 - ashpublications.org
Adenosine 5′-diphosphate (ADP) plays a central role in regulating platelet function by the
activation of the G protein–coupled receptors P2Y 1 and P2Y 12 . Although it is well …
activation of the G protein–coupled receptors P2Y 1 and P2Y 12 . Although it is well …
[HTML][HTML] PKCα regulates platelet granule secretion and thrombus formation in mice
…, JWM Heemskerk, AW Poole - The Journal of …, 2009 - Am Soc Clin Investig
… /017 to AW Poole; CH/03/003 to SP Watson); the Medical Research Council (MRC-65282
to SP Watson); and the NIH (NIHLB HL56652 to SW Whiteheart). AW Poole is a Biotechnology …
to SP Watson); and the NIH (NIHLB HL56652 to SW Whiteheart). AW Poole is a Biotechnology …
Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis
EO Agbani, AW Poole - Blood, The Journal of the American …, 2017 - ashpublications.org
Current understanding of how platelets localize coagulation to wound sites has come mainly
from studies of a subpopulation of activated platelets. In this review, we summarize data …
from studies of a subpopulation of activated platelets. In this review, we summarize data …
Coordinated membrane ballooning and procoagulant spreading in human platelets
…, PW Collins, JWM Heemskerk, I Hers, AW Poole - Circulation, 2015 - Am Heart Assoc
Background— Platelets are central to the process of hemostasis, rapidly aggregating at
sites of blood vessel injury and acting as coagulation nidus sites. On interaction with the …
sites of blood vessel injury and acting as coagulation nidus sites. On interaction with the …