… Subunit architecture is quite similar for 5-HT3A, B, C, E subunits whereas the 5-HT3D
subunit lacks most of the N-terminal domain including the Cys-loop (Niesler et al., 2003). The 5-…

The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although the …

Growth retardation resulting in short stature is a major concern for parents and due to its great
variety of causes, a complex diagnostic challenge for clinicians. A major locus involved in …

… Upregulation of miR-29a/b in the intestinal mucosa decreased levels of glutamine synthetase
90 , an important regulator of intestinal permeability and homeostasis, claudin-1 and NF-…

Background: Short stature affects approximately 2% of children, representing one of the more
frequent disorders for which clinical attention is sought during childhood. Despite assumed …

… We consider it likely that different subunit compositions of HTR3C, D, E as well as HTR3A
and B in the 5-HT 3 receptor contribute to the complexity of the 5-HT 3 receptor system and …

… 1 B). These findings confirm the predicted binding of miR-510 to the 3′-UTR of HTR3E
and demonstrate a dose-dependent reduction of reporter gene expression. Since the binding …

Short stature, with an incidence of 3 in 100, is a fairly frequent disorder in children. Idiopathic
short stature refers to patients who are short due to various unknown reasons. Mutations of …

… All subunits but the 5-HT 3C subunit led to a significant change of B max of the resulting …
3E , the B max value increased to 143.6 and 147.4% (p < 0.05) compared with the B max value …

Objective Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier
function partly by modulating the expression of tight junction (TJ) proteins. We have …