User profiles for C. Czajkowski

Cezary Czajkowski

Politechnika Wrocławska
Verified email at pwr.edu.pl
Cited by 126

Structural Requirements for Eszopiclone and Zolpidem Binding to the γ-Aminobutyric Acid Type-A (GABAA) Receptor Are Different

…, EV Morlock, KA Satyshur, C Czajkowski - Journal of medicinal …, 2008 - ACS Publications
… α 1 loop C, the carbonyl pointed up toward the tip of α 1 loop C and the dimethyl … C and
the dimethyl amide pointed down in the pocket toward α 1 H101 (ZPM-down-dock) (Figures 5c

Structural mechanisms underlying benzodiazepine modulation of the GABAA receptor

SM Hanson, C Czajkowski - Journal of Neuroscience, 2008 - Soc Neuroscience
… HEK293T cells were grown in minimum essential medium with Earle's salts (Invitrogen,
Grand Island, NY) containing 10% fetal bovine serum in a 37C incubator under 5% CO 2 …

Structure and dynamics of the GABA binding pocket: a narrowing cleft that constricts during activation

DA Wagner, C Czajkowski - Journal of Neuroscience, 2001 - Soc Neuroscience
… To acquire insight into the physicochemical environment of the loop C domain of the GABA
… with slowest reaction rate recorded at the most C-terminal residue tested (S209C, 120 M −1 s …

Mapping the agonist binding site of the gabaareceptor: Evidence for a β-strand

…, AR Evers, AF Davis, C Czajkowski - Journal of …, 1999 - Soc Neuroscience
… Twelve individual cysteine-substituted α 1 subunits were made in the region from α 1 Y59
to K70 and are denoted by a C above the corresponding wild-type α 1 residues. …

Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [γ2(R43Q)] found in human epilepsy

…, DA Wagner, C Czajkowski… - Proceedings of the …, 2002 - National Acad Sciences
The γ-aminobutyric acid type A (GABA A ) receptor mediates fast inhibitory synaptic transmission
in the CNS. Dysfunction of the GABA A receptor would be expected to cause neuronal …

The relative amount of cRNA coding for γ2 subunits affects stimulation by benzodiazepines in GABAA receptors expressed in Xenopus oocytes

…, R Baur, LM Sharkey, E Sigel, C Czajkowski - …, 2002 - Elsevier
Benzodiazepine (BZD) potentiation of GABA-activated Cl − -current (I GABA ) in recombinant
GABA A receptors requires the presence of the γ subunit. When α1, β2 and γ2S cRNA are …

Protein mobility and GABA-induced conformational changes in GABAA receptor pore-lining M2 segment

J Horenstein, DA Wagner, C Czajkowski… - Nature …, 2001 - nature.com
Protein movements underlying ligand-gated ion channel activation are poorly understood.
Here we used disulfide bond trapping to examine the proximity and mobility of cysteines …

Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine.

C Czajkowski, C Kaufmann… - Proceedings of the …, 1993 - National Acad Sciences
… with NaOH] for 20 min at 17C (32). The pieces were washed … ) sucrose and centrifuged at
4C in a Beckman Ti 50.2 rotor at … 3 nM), and holding at 18C overnight. The samples were then …

[HTML][HTML] The GABAA receptor α1 subunit Pro174–Asp191 segment is involved in GABA binding and channel gating

JG Newell, C Czajkowski - Journal of Biological Chemistry, 2003 - ASBMB
C, position of Asp 183 in relation to other core GABA-binding site residues α 1 Phe 64
and α 1 Arg 66 from loop D (yellow), in addition to β 2 Arg 207 and β 2 Tyr 205 of loop C (red). …

Experimental study on a large scale pulsating heat pipe operating at high heat loads, different adiabatic lengths and various filling ratios of acetone, ethanol, and …

C Czajkowski, AI Nowak, P Błasiak, A Ochman… - Applied Thermal …, 2020 - Elsevier
… section of 15 C ± 0.5 C . The thermal performance of the PHP is described by the thermal
resistance R which is defined as:(3) R = T e - T c Q where T e and T c are temperatures in the …