The immune system plays a major role in the surveillance and control of malignant cells,
with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient …

… This results in tissue factor-mediated thrombin generation, downregulation of physiological
anticoagulant mechanisms such as those involving Protein C and S, inhibition of fibrinolysis …

… C MA plot for genes increased or decreased by NECA in the indicated subsets. Significant
… C, D Mice were bled at day 8 post treatment. C The number of human T cells per µl of blood …

… Over the last 15 years, the mGluR5 ligand repertoire has thus grown to comprise one of the
most extensive selections of Class C pharmacological tool compounds and new ligands are …

Posttreatment recurrence of colorectal cancer, the third most lethal cancer worldwide, is often
driven by a subpopulation of cancer stem cells (CSC). The tight junction (TJ) protein claudin…

… (C) CK20 staining on tumours following subcutaneous injections of CTC lines. … (C)
Immunofluorescent staining of representative tumour spheres derived from single-cell clones of CTC …

… Based on 1 H- 13 C HMBC NMR and predicted 13 C chemical shifts, we assigned structure
50 to the product; see the Supporting Information for details. This result is contrary to the …

… the Ct value of the target of interest ( Δ C t = C t r e f e r e n c e – C t t a r g e t ). Subsequently…
by raising 2 to the power of the ΔΔCt ( 2 [ Δ C t s a m p l e – Δ C t c o n t r o l ] ). Only samples …

… All cells were cultured in a humidified incubator at 37 C and 5% CO 2 . … 1A–C). DLD1
cells treated with as low as 300 nM PSB-603 also produced a diminished MTT signal (Fig. 1A). …

… However, no crystal structures of the 7TMD of mGluR5 or any other class C GPCRs are
available. This fact limits the structural insights into allosteric binding pockets located within the …