… However, lower MIC values were observed with dibenzo[b,d]furan and dibenzo[b,d]thiophene
triazole conjugates in the series (MICs = 0.78 to 25 µg/mL) in comparison to those …

… Food intake was not significantly affected by nicotine or cytisine in POMC KO mice at two
different doses (D). Furthermore, knockdown of Mc4r by AAV-shRNAs in the PVN [detected by …

… D. A flattened (c,c) conformation will increase the dipole moment to 1.90 D, whereas the dipole
moment is 1.84 D … However, the experimental value obtained was 2.02 D, which excluded …

In an effort to develop selective radioligands for in vivo imaging of neuronal nicotinic
acetylcholine receptors (nAChRs), we synthesized 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine (5-…

… be less than 1 μM to the receptor; ii) agonist activity (E max ) less than 10% of the E max of
an agonist; iii) the inhibiting receptor activation by an agonist via desensitization (IC 50(D) ) …

… based on the measured IC 50 values and K d =10 pM for binding of (±)-[ 3 H]epibatidine
and K d =1 nM for [ 3 H]MLA. The K d values were obtained from five independent experiments …

3-(2(S)-Azetidinylmethoxy)pyridine (A-85380) has been identified recently as a ligand with
high affinity for nicotinic acetylcholine receptors (nAChRs). Here we report the synthesis and …

… 2D). No region with reduced tracer uptake was found. … (D) Statistical parametric mapping
analysis using proportional scaling; the depicted areas exceed a voxelbased statistical …

Nicotine and other nicotinic agents are thought to regulate mood in human subjects and have
antidepressant-like properties in animal models. Recent studies have demonstrated that …

As part of our program aimed at optimizing therapeutic effects over toxic effects (as
observed in the naturally occurring nicotinic acetylcholine receptor modulators (−)-nicotine, (−)-…