User profiles for E. A. Goncharova
Elena GoncharovaProfessor of Medicine, University of California, Davis Verified email at ucdavis.edu Cited by 4794 |
Aptamers as modular components of therapeutic nucleic acid nanotechnology
…, W Ke, J McMillan, EA Goncharova… - Therapeutic RNA …, 2021 - taylorfrancis.com
Nucleic acids play a central role in all domains of life, either as genetic blueprints or as
regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid (RNA) …
regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid (RNA) …
[HTML][HTML] Translational Advances in the Field of Pulmonary Hypertension.From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting …
Pulmonary arterial hypertension (PAH) has been frequently compared with a type of malignant
disease and has an incredible number of pathogenic mechanisms similar to cancer (1–3)…
disease and has an incredible number of pathogenic mechanisms similar to cancer (1–3)…
[HTML][HTML] Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: a role for the TSC2 tumor suppressor gene in pulmonary …
EA Goncharova, DA Goncharov, A Eszterhas… - Journal of Biological …, 2002 - ASBMB
Although the cellular functions ofTSC2 and its protein product, tuberin, are not known, somatic
mutations in the TSC2 tumor suppressor gene are associated with tumor development in …
mutations in the TSC2 tumor suppressor gene are associated with tumor development in …
[HTML][HTML] mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects
EA Goncharova - The FASEB Journal, 2013 - ncbi.nlm.nih.gov
… Goncharova 1 … Goncharova, EA mTOR and vascular remodeling in lung diseases: current …
, Ihida-Stansbury K., Jones PL, Goncharova EA (2011) mTOR is required for pulmonary arterial …
, Ihida-Stansbury K., Jones PL, Goncharova EA (2011) mTOR is required for pulmonary arterial …
SIRT3–AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure …
…, CM St. Croix, A Garcia-Ocaña, EA Goncharova… - Circulation, 2016 - Am Heart Assoc
Background— Pulmonary hypertension associated with heart failure with preserved ejection
fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic …
fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic …
Vitamin D inhibits growth of human airway smooth muscle cells through growth factor‐induced phosphorylation of retinoblastoma protein and checkpoint kinase 1
…, HW Fogle, P Lim, EA Goncharova… - British journal of …, 2009 - Wiley Online Library
Background and purpose: Airway remodelling in asthma is manifested, in part, as increased
airway smooth muscle (ASM) mass, reflecting myocyte proliferation. We hypothesized that …
airway smooth muscle (ASM) mass, reflecting myocyte proliferation. We hypothesized that …
PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells
EA Goncharova, AJ Ammit, C Irani… - … of Physiology-Lung …, 2002 - journals.physiology.org
Human vascular smooth muscle cell proliferation and migration contribute to vascular remodeling
in pulmonary hypertension and atherosclerosis. The precise mechanisms that regulate …
in pulmonary hypertension and atherosclerosis. The precise mechanisms that regulate …
Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial …
…, RM Tuder, SM Kawut, EA Goncharova - Circulation, 2014 - Am Heart Assoc
Background— Enhanced proliferation, resistance to apoptosis, and metabolic shift to
glycolysis of pulmonary arterial vascular smooth muscle cells (PAVSMCs) are key …
glycolysis of pulmonary arterial vascular smooth muscle cells (PAVSMCs) are key …
mTORC 1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts
…, D Álvarez, JC Sembrat, EA Goncharova… - Aging cell, 2016 - Wiley Online Library
Idiopathic pulmonary fibrosis ( IPF ) is a chronic, progressive, and usually lethal disease
associated with aging. However, the molecular mechanisms of the aging process that contribute …
associated with aging. However, the molecular mechanisms of the aging process that contribute …
mTORC2 is required for proliferation and survival of TSC2-null cells
EA Goncharova, DA Goncharov, H Li… - … and cellular biology, 2011 - Taylor & Francis
Mutational inactivation of the tumor suppressor tuberous sclerosis complex 2 (TSC2)
constitutively activates mTORC1, increases cell proliferation, and induces the pathological …
constitutively activates mTORC1, increases cell proliferation, and induces the pathological …