Nucleic acids play a central role in all domains of life, either as genetic blueprints or as
regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid (RNA) …

Pulmonary arterial hypertension (PAH) has been frequently compared with a type of malignant
disease and has an incredible number of pathogenic mechanisms similar to cancer (1–3)…

Although the cellular functions ofTSC2 and its protein product, tuberin, are not known, somatic
mutations in the TSC2 tumor suppressor gene are associated with tumor development in …

… Goncharova 1 … Goncharova, EA mTOR and vascular remodeling in lung diseases: current …
, Ihida-Stansbury K., Jones PL, Goncharova EA (2011) mTOR is required for pulmonary arterial …

Background— Pulmonary hypertension associated with heart failure with preserved ejection
fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic …

Background and purpose: Airway remodelling in asthma is manifested, in part, as increased
airway smooth muscle (ASM) mass, reflecting myocyte proliferation. We hypothesized that …

Human vascular smooth muscle cell proliferation and migration contribute to vascular remodeling
in pulmonary hypertension and atherosclerosis. The precise mechanisms that regulate …

Background— Enhanced proliferation, resistance to apoptosis, and metabolic shift to
glycolysis of pulmonary arterial vascular smooth muscle cells (PAVSMCs) are key …

Idiopathic pulmonary fibrosis ( IPF ) is a chronic, progressive, and usually lethal disease
associated with aging. However, the molecular mechanisms of the aging process that contribute …

Mutational inactivation of the tumor suppressor tuberous sclerosis complex 2 (TSC2)
constitutively activates mTORC1, increases cell proliferation, and induces the pathological …