The human histamine receptors hH 1 R and hH 2 R constitute important drug targets, and
hH 3 R and hH 4 R have substantial potential in this area. Considering the species-specificity …

Expression and function of histamine H 4 R in central and peripheral nervous system have
been a matter of controversy for more than a decade. The scientific discussion is often limited …

The histamine H 4 receptor (H 4 R) is expressed in several cell types of the immune system
and is assumed to play an important pro-inflammatory role in various diseases, including …

The human histamine H 4 -receptor (hH 4 R) is expressed in mast cells and eosinophils and
mediates histamine (HA)-induced chemotaxis via G i -proteins. For a detailed investigation …

Histamine, which is synthesized by histidine decarboxylase (HDC), does not only modulate
the immune system, but is also acting as a neurotransmitter. Histaminergic neurons project …

Histamine is a biogenic amine that exerts its biological effects as a neurotransmitter and local
mediator via four histamine receptor (HR) subtypes (H x Rs) – H 1 R, H 2 R, H 3 R, and H 4 …

It is assumed that many G protein-coupled receptors (GPCRs) are restrained in an inactive
state by the “ionic lock,” an interaction between an arginine in transmembrane domain (TM) 3 …

Histamine H 3 and H 4 receptors are highly related G protein-coupled receptors. Preclinical
and clinical data strongly suggest the potential therapeutic application of selectively acting …

The Sf9 cell/baculovirus expression system is widely used for high-level protein expression,
often with the purpose of purification. However, proteins may also be functionally expressed …

The human histamine H 4 receptor (hH 4 R) is a promising new target in the therapy of
inflammatory diseases and disorders of the immune system. For the development of new H 4 R …