Anti-inflammatory actions of pentacyclic triterpenes
H Safayhi, ER Sailer - Planta medica, 1997 - thieme-connect.com
Pentacyclic triterpenes (PTs) as aglycones of saponins have a wide distribution in plants, and
many of them have been used as anti-inflammatory remedies in folk medicine. This survey …
many of them have been used as anti-inflammatory remedies in folk medicine. This survey …
Inhibition by boswellic acids of human leukocyte elastase
H Safayhi, B Rall, ER Sailer, HPT Ammon - Journal of Pharmacology and …, 1997 - ASPET
Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of
frankincense, block leukotriene biosynthesis and exert potent anti-inflammatory effects. …
frankincense, block leukotriene biosynthesis and exert potent anti-inflammatory effects. …
Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation
H Safayhi, J Sabieraj, ER Sailer, HPT Ammon - Planta medica, 1994 - thieme-connect.com
Matricine and its transformation product chamazulene are constituents of chamomile
extracts. Both have been demonstrated to exert anti-inflammatory activity in vivo. Since …
extracts. Both have been demonstrated to exert anti-inflammatory activity in vivo. Since …
Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid.
H Safayhi, ER Sailer, HP Ammon - Molecular pharmacology, 1995 - ASPET
The formation of 5-lipoxygenase (EC 1.13.11.34) products from endogenous substrate by
intact rat neutrophilic granulocytes and from exogenous arachidonic acid by rat granulocyte …
intact rat neutrophilic granulocytes and from exogenous arachidonic acid by rat granulocyte …
Acetyl-11-keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity.
ER Sailer, LR Subramanian, B Rall… - British journal of …, 1996 - ncbi.nlm.nih.gov
5-Lipoxygenase (5-LOX) products from endogenous arachidonic acid in ionophore-stimulated
peritoneal polymorphonuclear leukocytes (PMNL) and from exogenous substrate (20 …
peritoneal polymorphonuclear leukocytes (PMNL) and from exogenous substrate (20 …
Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity
…, S Winter, P Groscurth, H Safayhi, ER Sailer… - British journal of …, 1999 - nature.com
Steroids are essential for the control of oedema in human malignant glioma patients but
may interfere with the efficacy of chemotherapy. Boswellic acids are phytotherapeutic anti-…
may interfere with the efficacy of chemotherapy. Boswellic acids are phytotherapeutic anti-…
Acetyl-11-keto-β-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I
…, C Zehrer, D Niethammer, ER Sailer… - … of Pharmacology and …, 1999 - ASPET
Antiproliferative action of different pentacyclic triterpenes has repeatedly been reported, and
some lipoxygenase inhibitors have been shown to induce cell death in various cell systems. …
some lipoxygenase inhibitors have been shown to induce cell death in various cell systems. …
Characterization of an acetyl‐11‐keto‐β‐boswellic acid and arachidonate‐binding regulatory site of 5‐lipoxygenase using photoaffinity labeling
ER Sailer, S Schweizer, SE Boden… - European journal of …, 1998 - Wiley Online Library
AKBA (acetyl‐11‐keto‐β‐boswellic acid), a natural pentacyclic triterpene, is an orally active
leukotriene‐synthesis inhibitor, which acts by a 5‐lipoxygenase−directed, non‐redox, non‐…
leukotriene‐synthesis inhibitor, which acts by a 5‐lipoxygenase−directed, non‐redox, non‐…
5-Lipoxygenase inhibition by acetyl-11-keto-β-boswellic acid (AKBA) by a novel mechanism
H Safayhi, ER Sailer, HPT Ammon - Phytomedicine, 1996 - Elsevier
… In addition, by using a series of synthetically modified boswellic acid derivatives (Sailer et
aI., 1996 b) we observed that the pentacyclic triterpene ring system is crucial for binding to the …
aI., 1996 b) we observed that the pentacyclic triterpene ring system is crucial for binding to the …
A test system for leukotriene synthesis inhibitors based on the in-vitro differentiation of the human leukemic cell lines HL-60 and Mono Mac 6
O Werz, N Schneider, M Brungs, ER Sailer… - Naunyn-Schmiedeberg's …, 1997 - Springer
Differentiation of HL-60 cells along the granulocytic lineage by DMSO in the presence of
transforming growth factor-β and low concentrations of 1,25-dihydroxyvitamin D 3 leads to the …
transforming growth factor-β and low concentrations of 1,25-dihydroxyvitamin D 3 leads to the …