Pentacyclic triterpenes (PTs) as aglycones of saponins have a wide distribution in plants, and
many of them have been used as anti-inflammatory remedies in folk medicine. This survey …

Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of
frankincense, block leukotriene biosynthesis and exert potent anti-inflammatory effects. …

Matricine and its transformation product chamazulene are constituents of chamomile
extracts. Both have been demonstrated to exert anti-inflammatory activity in vivo. Since …

The formation of 5-lipoxygenase (EC 1.13.11.34) products from endogenous substrate by
intact rat neutrophilic granulocytes and from exogenous arachidonic acid by rat granulocyte …

5-Lipoxygenase (5-LOX) products from endogenous arachidonic acid in ionophore-stimulated
peritoneal polymorphonuclear leukocytes (PMNL) and from exogenous substrate (20 …

Steroids are essential for the control of oedema in human malignant glioma patients but
may interfere with the efficacy of chemotherapy. Boswellic acids are phytotherapeutic anti-…

Antiproliferative action of different pentacyclic triterpenes has repeatedly been reported, and
some lipoxygenase inhibitors have been shown to induce cell death in various cell systems. …

AKBA (acetyl‐11‐keto‐β‐boswellic acid), a natural pentacyclic triterpene, is an orally active
leukotriene‐synthesis inhibitor, which acts by a 5‐lipoxygenase−directed, non‐redox, non‐…

… In addition, by using a series of synthetically modified boswellic acid derivatives (Sailer et
aI., 1996 b) we observed that the pentacyclic triterpene ring system is crucial for binding to the …

Differentiation of HL-60 cells along the granulocytic lineage by DMSO in the presence of
transforming growth factor-β and low concentrations of 1,25-dihydroxyvitamin D 3 leads to the …