Through expression of the cloned mouse (mSlo) or human (hSlo) large-conductance (BK)
Ca(2+)-activated K+ channel in Xenopus laevis oocytes and HEK 293 cells, we characterized …

A series of racemic 3-(trans-2-aminomethylcyclopentyl)indoles was synthesized and found
to have potent binding to the human serotonin transporter (hSERT). The most active analog …

A series of N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines
were prepared and evaluated as potential CRF 1 R PET imaging …

Analyte solvent and injection volume were examined as parameters that affect peak elution
during method development for semipreparative RP HPLC purification. Analytical and …

The synthesis of a series of 3-β-hydroxyethyl-4-arylquinolin-2-ones is described. These
compounds contain hydrophilic and hydrophobic substituents ortho to the phenolic OH in the C …

A series of conformationally restricted homotryptamines has been synthesized and shown to
be potent inhibitors of hSERT. Conformational restriction of the homotryptamine side chain …

Many 3-substitued-4-arylquinolinones containing an ortho substituent on the aryl ring were
known as a class of compounds with maxi-K opening activity. These quinolinones, which …

Synthetic macrocyclic peptides with natural and unnatural amino acids have gained
considerable attention from a number of pharmaceutical/biopharmaceutical companies in recent …

A series of pyrazinones were prepared and evaluated as potential CRF1R PET imaging
agents. Optimization of their CRF1R binding potencies and octanol–phosphate buffer phase …

The synthesis and iodination of a structural analogue of the specific large‐conductance
calcium‐activated potassium (BK) channel blocker, iberiotoxin (IbTX), a 37‐amino acid scorpion …