Transforming growth factor β1 (TGF-β1) is a potent fibrotic factor responsible for the
synthesis of extracellular matrix. TGF-β1 acts through the TGF-β type I and type II receptors to …

Progressive kidney fibrosis precedes end-stage renal failure in up to a third of patients with
diabetes mellitus. Elevated intra-renal transforming growth factor-β (TGF-β) is thought to …

Increased Rho kinase (ROCK) activity contributes to smooth muscle contraction and regulates
blood pressure homeostasis. We hypothesized that potent and selective ROCK inhibitors …

SB-525334 (6-[2-tert-butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline) has
been characterized as a potent and selective inhibitor of the transforming growth factor-β1 (TGF-…

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) have been
recently derived and are used for basic research, cardiotoxicity assessment, and phenotypic …

… Because the cellular data suggested that asoprisnil was a weak partial agonist, we
examined the ability of asoprisnil to oppose E 2 in the rat uterotrophic model. In this model, P 4 …

… The amido compounds 13a−e were synthesized by coupling the acid 9 with amines in
the presence of 1-hydroxybenzotriazole (HOBT) and 1-ethyl-3-(3-dimethylaminopropyl)…

Acute infusion of hypertonic fluid increases mean arterial pressure (MAP) in part by elevating
nonrenal sympathetic activity. However, it is not known whether chronic, physiological …

TGF-|β|, and its type 1 (ALK5) receptor, are critical to the pathogenesis of fibrosis. In toxicologic
studies of 4 or more days in 10-week-old Sprague–Dawley rats, using an ALK5 inhibitor (…

Endometriosis, defined as the presence of endometrial glands and stroma at extra-uterine
sites, is a gynecological condition that affects women of reproductive age. Consistent with its …