… This figure was originally published by GA Rutter in (168) (reprinted with permission). …
This figure was originally published by GA Rutter in (165) (reprinted with permission). …

Mitochondrial Ca 2+ transport was initially considered important only in buffering of cytosolic
Ca 2+ by acting as a “sink” under conditions of Ca 2+ overload. The main regulator of ATP …

… should be addressed (e-mail garutter@bris.ac.uk). … However, bioinformatics analysis (GA
Rutter, unpublished work) reveals … Tsuboi and GA Rutter, unpublished work). Two key β-cell ion …

In recent years, mitochondria have emerged as important targets of agonist-dependent
increases in cytosolic Ca 2+ concentration. Here, we analyzed the significance of Ca 2+ signals …

Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here …

We developed genetically encoded fluorescence resonance energy transfer (FRET)-based
sensors that display a large ratiometric change upon Zn 2+ binding, have affinities that span …

The arrangement of β cells within islets of Langerhans is critical for insulin release through
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …

OBJECTIVE Zinc ions are essential for the formation of hexameric insulin and hormone
crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 …

MicroRNAs (miRNAs) are short non-coding RNAs that have been implicated in fine-tuning
gene regulation, although the precise roles of many are still unknown. Pancreatic …

Stimulation of hepatocytes with vasopressin evokes increases in cytosolic free Ca 2+([Ca 2+]
c) that are relayed into the mitochondria, where the resulting mitochondrial Ca 2+([Ca 2+] m…