Drug transport by organic anion transporters (OATs)
G Burckhardt - Pharmacology & therapeutics, 2012 - Elsevier
Common to all so far functionally characterized Organic Anion Transporters (OATs) is their
broad substrate specificity and their ability to exchange extracellular against intracellular …
broad substrate specificity and their ability to exchange extracellular against intracellular …
Transport of organic anions across the basolateral membrane of proximal tubule cells
BC Burckhardt, G Burckhardt - Reviews of physiology, biochemistry and …, 2003 - Springer
Renal proximal tubules secrete diverse organic anions (OA) including widely prescribed
anionic drugs. Here, we review the molecular properties of cloned transporters involved in …
anionic drugs. Here, we review the molecular properties of cloned transporters involved in …
Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles
AN Rizwan, G Burckhardt - Pharmaceutical research, 2007 - Springer
The human organic anion transporters OAT1, OAT2, OAT3, OAT4 and URAT1 belong to a
family of poly-specific transporters mainly located in kidneys. Selected OATs occur also in liver…
family of poly-specific transporters mainly located in kidneys. Selected OATs occur also in liver…
Human renal organic anion transporter 4 operates as an asymmetric urate transporter
Y Hagos, D Stein, B Ugele, G Burckhardt… - Journal of the American …, 2007 - journals.lww.com
Human organic anion transporter 4 (hOAT4) is located at the apical membrane of proximal
tubule cells and involved in renal secretion and reabsorption of endogenous substances as …
tubule cells and involved in renal secretion and reabsorption of endogenous substances as …
Gender differences in kidney function
…, WE Budach, C Wanke, A Bahn, G Burckhardt - … -European Journal of …, 2007 - Springer
Sex hormones influence the development of female (F) and male (M) specific traits and
primarily affect the structure and function of gender-specific organs. Recent studies also …
primarily affect the structure and function of gender-specific organs. Recent studies also …
[HTML][HTML] Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
…, W Krick, BC Burckhardt, I Sabolic, G Burckhardt - Journal of Biological …, 2008 - ASBMB
The orphan transporter hORCTL3 (human organic cation transporter like 3; SLC22A13) is
highly expressed in kidneys and to a weaker extent in brain, heart, and intestine. hORCTL3-…
highly expressed in kidneys and to a weaker extent in brain, heart, and intestine. hORCTL3-…
Structure of renal organic anion and cation transporters
G Burckhardt, NA Wolff - American Journal of Physiology …, 2000 - journals.physiology.org
Here we review the structural and functional properties of organic anion transporters (OAT1,
OAT2, OAT3) and organic cation transporters (OCTN1, OCTN2, OCT1, OCT2, OCT3), some …
OAT2, OAT3) and organic cation transporters (OCTN1, OCTN2, OCT1, OCT2, OCT3), some …
In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy
G Burckhardt, BC Burckhardt - Drug Transporters, 2011 - Springer
Organic anion transporters 1-10 (OAT1-10) and the urate transporter 1 (URAT1) belong to
the SLC22A gene family and accept a huge variety of chemically unrelated endogenous and …
the SLC22A gene family and accept a huge variety of chemically unrelated endogenous and …
Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition
…, A Bahn, H Endou, G Burckhardt… - American Journal …, 2004 - journals.physiology.org
… The pellets were discarded, and the supernatants were then centrifuged at 150,000 g for
1 h (ultracentrifuge Sorvall OTD-Combi, rotor T-875). The final pellets (total cell membranes) …
1 h (ultracentrifuge Sorvall OTD-Combi, rotor T-875). The final pellets (total cell membranes) …
Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux
A Bakhiya, A Bahn, G Burckhardt, N Wolff - Cellular physiology and …, 2003 - karger.com
… 13 Burckhardt BC, Burckhardt G: Transport of organic anions across the basolateral … 24
Wolff NA, Werner A, Burkhardt S, Burckhardt G: Expression cloning and characterization of a …
Wolff NA, Werner A, Burkhardt S, Burckhardt G: Expression cloning and characterization of a …