Studies of inclusion complexes of natural and modified cyclodextrin with (+) catechin by NMR and molecular modeling

C Jullian, S Miranda, G Zapata-Torres… - Bioorganic & medicinal …, 2007 - Elsevier
The aim of this paper is to describe the inclusion properties and the factors affecting the
complexation selectivity and stabilization of catechin (CA) into β-cyclodextrin (β-CD) and two of …

Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives: structure–activity relationships

…, C Carrau, R Silveira, G Zapata-Torres… - Biochemical …, 1997 - Elsevier
The monoamine oxidase (MAO) inhibitory properties of a series of amphetamine derivatives
with different substituents at or around the para position of the aromatic ring were evaluated. …

Revealing monoamine oxidase B catalytic mechanisms by means of the quantum chemical cluster approach

G Zapata-Torres, A Fierro… - Journal of Chemical …, 2015 - ACS Publications
Two of the possible catalytic mechanisms for neurotransmitter oxidative deamination by
monoamine oxidase B (MAO B), namely, polar nucleophilic and hydride transfer, were …

Molecular determinants for competitive inhibition of α4β2 nicotinic acetylcholine receptors

…, BK Cassels, S Wonnacott, G Zapata-Torres… - Molecular …, 2010 - ASPET
… Rats (250–350 g) were killed by cervical dislocation, and the striata were rapidly dissected.
… The overall average g factor for the best structures was −0.20. This value is a good indicator …

[HTML][HTML] Major histocompatibility complex class I-related chain A (MICA) allelic variants associate with susceptibility and prognosis of gastric cancer

…, R Armisen, DJ Matthies, G Zapata-Torres… - Frontiers in …, 2021 - frontiersin.org
Gastric cancer (GC) is the fifth most prevalent type of cancer worldwide. Gastric tumor cells
express MICA protein, a ligand to NKG2D receptor that triggers natural killer (NK) cells …

Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins

…, J Morales-Montecinos, G Zapata-Torres… - Bioorganic & medicinal …, 2008 - Elsevier
The slightly water-soluble 5-nitroindazole derivative (5-NI) and its inclusion with either β-cyclodextrin
(βCD) or Heptakis (2,6-di-O-methyl)-β-cyclodextrin (DMβCD) were investigated. …

Influence of DMβCD on the Interaction of Copper(II) Complex of 6-Hydroxychromone-3-carbaldehyde-3-hydroxybenzoylhydrazine with ctDNA

…, C Quiroga-Campano, G Zapata-Torres… - ACS …, 2020 - ACS Publications
The interaction mechanism between a scarcely soluble copper(II) complex of Cu(II)-6-hydroxychromone-3-carbaldehyde-(3′-hydroxy)benzoylhydrazone
(CuCHz) in aqueous solution …

[HTML][HTML] Racemic salsolinol and its enantiomers act as agonists of the μ-opioid receptor by activating the Gi protein-adenylate cyclase pathway

…, V Vasiliou, G Zapata-Torres… - Frontiers in Behavioral …, 2017 - frontiersin.org
… To assess the activation of the μ-opioid receptor through the recruitment of G protein
signaling pathway, we used the cyclic adenosine monophosphate (cAMP) Hunter ® eXpress G

Effects of natural flavones and flavonols on the kinase activity of Cdk5

G Zapata-Torres, F Opazo, C Salgado… - Journal of natural …, 2004 - ACS Publications
A number of natural and synthetic flavonoids have been assessed previously with regard to
their effects on the activity of cyclin-dependent kinases (Cdk1 and -2) related to the inhibition …

Identification of VEGFR2 as the histatin-1 receptor in endothelial cells

…, JGM Bolscher, CAM Wilson, G ZapataTorres… - Biochemical …, 2022 - Elsevier
Histatin-1 is a salivary peptide with antimicrobial and wound healing promoting activities,
which was previously shown to stimulate angiogenesis in vitro and in vivo via inducing …