Aging is associated with increased incidence and/or severity of neurodegenerative pathologies.
Oxygen‐mediated events are being considered as possible mechanisms responsible …

The mechanism of delayed neurotoxicity, triggered by glutamate, was studied in 7-8-day-old
primary cultures of rat cerebellar granule cells. Treatment of cultures for 15 min with 50 …

Typically, cyclooxygenases (COXs) and 5-lipoxygenase (5-LOX), enzymes that generate
biologically active lipid molecules termed eicosanoids, are considered inflammatory. Hence, …

Using a sensitive histofluorescence staining method that allows for a quantitation of neuronal
death, we compared the protective effects of gangliosides (a group of naturally occurring …

The action of antidepressants on cell proliferation {bromodeoxyuridine (BrdU) or [ 3 H]thymidine
incorporation} was studied in the adult rat hippocampus in vivo and in neural precursors …

… we used allowsrecirculationtooccur after 1 h of focal ischemia. … in the left
frontoparietalcortexas earlyas 4 h afterleftMCAO and a much greaterlesionat 6 h afterMCAO. …

Singlet oxygen (O 2 [ 1 Δg]) is a very reactive molecule that can be produced by living cells
and may contribute to cytotoxicity. The pineal hormone melatonin has been reported to …

Nuclear epigenetics of the mammalian brain is modified during aging. Little is known about
epigenetic modifications of mitochondrial DNA (mtDNA). We analyzed brain samples of 4- …

… activity 24 h after injection (e) and almost completely abolished it 48 h (f) and 72 h (g) after
injection. The presence of the reporter lacZ mRNA was abolished 48 and 72 h after lacZ …

… Aba-seq and bioinformatics to analyze the results obtained from mouse mtDNA, these authors
found the highest 5hmC site density in the mitochondrial genome in both CG and CH (H=A…