User profiles for J. E. Saavedra
 | Juan Esteban SaavedraLecturer in Public Policy, Harvard Kennedy School Verified email at hks.harvard.edu Cited by 1969 |
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects
…, DA Wink, TM Dunams, JE Saavedra… - Journal of medicinal …, 1991 - ACS Publications
(ENo) were 1.5, 0.73, 1.9, 0.54, and 0.001 mol/mol of starting material consumed, respectively,
as determined from the integrated chemiluminescence response. Vasodilatory activities …
as determined from the integrated chemiluminescence response. Vasodilatory activities …
Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated …
…, JF Darbyshire, RW Nims, JE Saavedra… - Chemical research in …, 1993 - ACS Publications
A recent discovery in mammalian biology has been the important physiological role that
nitric oxide plays in blood pressure regulation, neurotransmission, macrophage-in-duced …
nitric oxide plays in blood pressure regulation, neurotransmission, macrophage-in-duced …
Preparation and characterization of hydrophobic polymeric films that are thromboresistant via nitric oxide release
KA Mowery, MH Schoenfisch, JE Saavedra, LK Keefer… - Biomaterials, 2000 - Elsevier
The preparation of hydrophobic polymer films (polyurethane and poly(vinyl chloride))
containing nitric oxide (NO)-releasing diazeniumdiolate functions is reported as a basis for …
containing nitric oxide (NO)-releasing diazeniumdiolate functions is reported as a basis for …
Nitric Oxide-Releasing Polymers Containing the [N(O)NO]- Group
…, JA Hrabie, ML Citro, JE Saavedra… - Journal of medicinal …, 1996 - ACS Publications
Ions of structure X[N(O)NO] - display broad-spectrum pharmacological activity that correlates
with the rate and extent of their spontaneous, first-order decomposition to nitric oxide when …
with the rate and extent of their spontaneous, first-order decomposition to nitric oxide when …
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl
Experimental evidence suggests that nitric oxide (NO) and hydrogen sulfide (H 2 S) signaling
pathways are intimately intertwined, with mutual attenuation or potentiation of biological …
pathways are intimately intertwined, with mutual attenuation or potentiation of biological …
Chemistry of the diazeniumdiolates. 2. Kinetics and mechanism of dissociation to nitric oxide in aqueous solution
KM Davies, DA Wink, JE Saavedra… - Journal of the American …, 2001 - ACS Publications
Diazeniumdiolate ions of structure R 2 N[N(O)NO] - (1) are of pharmacological interest because
they spontaneously generate the natural bioregulatory species, nitric oxide (NO), when …
they spontaneously generate the natural bioregulatory species, nitric oxide (NO), when …
Targeting Nitric Oxide (NO) Delivery in Vivo. Design of a Liver-Selective NO Donor Prodrug That Blocks Tumor Necrosis Factor-α-Induced Apoptosis and Toxicity in …
JE Saavedra, TR Billiar, DL Williams… - Journal of medicinal …, 1997 - ACS Publications
We have designed a drug that protects the liver from apoptotic cell death by organ-selective
pharmacological generation of the bioregulatory agent, nitric oxide (NO). The discovery …
pharmacological generation of the bioregulatory agent, nitric oxide (NO). The discovery …
Measuring fifteen endogenous estrogens simultaneously in human urine by high-performance liquid chromatography-mass spectrometry
…, JM Roman, HJ Issaq, R Falk, JE Saavedra… - Analytical …, 2005 - ACS Publications
A sensitive, specific, accurate, and precise high-performance liquid chromatography-electrospray
ionization-tandem mass spectrometry method for measuring the absolute quantities of …
ionization-tandem mass spectrometry method for measuring the absolute quantities of …
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic
J Liu, H Chen, DS Miller, JE Saavedra, LK Keefer… - Molecular …, 2001 - ASPET
Recent work shows that long-term exposure to low levels of arsenite induces malignant
transformation in a rat liver epithelial cell line. Importantly, these chronic arsenic-exposed (CAsE) …
transformation in a rat liver epithelial cell line. Importantly, these chronic arsenic-exposed (CAsE) …
JS-K, a Glutathione/Glutathione S-Transferase-activated Nitric Oxide Donor of the Diazeniumdiolate Class with Potent Antineoplastic Activity
PJ Shami, JE Saavedra, LY Wang, CL Bonifant… - Molecular cancer …, 2003 - AACR
We have previously shown that nitric oxide (NO) inhibits growth and induces differentiation
and apoptosis in acute myeloid leukemia cells, with the HL-60 human myeloid leukemia line …
and apoptosis in acute myeloid leukemia cells, with the HL-60 human myeloid leukemia line …