Understanding intratumoral heterogeneity—the molecular variation among cells within a
tumor—promises to address outstanding questions in cancer biology and improve the …

Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions
including regulation of innate immunity and inflammation, cell proliferation, cell migration and …

The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of
various cellular processes, including cell death, immune and inflammatory responses, cell …

Phosphorylation is an essential process in biological events and is considered critical for
biological functions. In tissues, protein phosphorylation mainly occurs on tyrosine (Tyr), serine (…

Tumours are often composed of a multitude of malignant clones that are genomically unique,
and only a few of them may have the ability to escape cancer therapy and grow as …

Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal
interactive network involved in this process remains unclear. Here, we optimized the use …

Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function
to facilitate tumor cell death. Here we have evaluated the efficacy of the preclinical Smac-…

… (H to K) Representative of average distribution and nonlinear cosinor fitting of baseline
day 4 (H and J) and after 1 and 6 days of imposed light phase feeding rhythm (I and K) for …

Although originally described as transcriptional activator, SPI1/PU.1, a major player in
haematopoiesis whose alterations are associated with haematological malignancies, has the …

… Statistics in g–j are shown for the indicated tissues (n≥3±SD). The experiment is
representative of two independent experiments … Jean Berthelet & Krishnaraj Rajalingam …