Pyruvate protects neurons against hydrogen peroxide-induced toxicity
S Desagher, J Glowinski, J Prémont - Journal of Neuroscience, 1997 - Soc Neuroscience
Hydrogen peroxide (H 2 O 2 ) is suspected to be involved in numerous brain pathologies such
as neurodegenerative diseases or in acute injury such as ischemia or trauma. In this study…
as neurodegenerative diseases or in acute injury such as ischemia or trauma. In this study…
[HTML][HTML] Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice
The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related
kinase B (TrkB) have emerged as key mediators in the pathophysiology of several mood …
kinase B (TrkB) have emerged as key mediators in the pathophysiology of several mood …
Glutamate-dependent phosphorylation of elongation factor-2 and inhibition of protein synthesis in neurons
…, J Glowinski, AC Nairn, J Prémont - Journal of …, 1997 - Soc Neuroscience
Postischemic delayed neuronal death is attributed to excitotoxic activation of glutamate
receptors. It is preceded by a persistent inhibition of protein synthesis, the molecular basis of …
receptors. It is preceded by a persistent inhibition of protein synthesis, the molecular basis of …
Sphingosine‐1‐phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades
A Pébay, M Toutant, J Prémont… - European Journal of …, 2001 - Wiley Online Library
Sphingosine‐1‐phosphate (S1P) is a potent lysophospholipid mediator mostly released by
activated platelets. It is involved in several functions in peripheral tissues, but its effects in the …
activated platelets. It is involved in several functions in peripheral tissues, but its effects in the …
Increase in External Glutamate and NMDA Receptor Activation Contribute to H2O2‐Induced Neuronal Apoptosis
…, M Israël, J Glowinski, J Prémont - Journal of …, 1999 - Wiley Online Library
: The present study aims to investigate the role of extracellular glutamate and NMDA receptor
stimulation in the neuronal death induced by a transient exposure to H 2 O 2 of cultured …
stimulation in the neuronal death induced by a transient exposure to H 2 O 2 of cultured …
Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain
…, J Glowinski, V Rogemond, J Prémont… - Journal of …, 2005 - Wiley Online Library
CRMP1, CRMP2, and CRMP5 have been identified as cytosolic proteins relaying semaphorin
3A signalling, one of the molecular cues conducting axon and dendrite growth and …
3A signalling, one of the molecular cues conducting axon and dendrite growth and …
[HTML][HTML] Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice
…, C Rose, JP Guilloux, C Pilon, A Dranovsky, J Prémont - PloS one, 2010 - journals.plos.org
In the last decades, few mechanistically novel therapeutic agents have been developed to
treat mental and neurodegenerative disorders. Numerous studies suggest that targeting …
treat mental and neurodegenerative disorders. Numerous studies suggest that targeting …
Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex
Despite the tremendous importance of D1 and NMDA receptors to cognition (working memory,
executive functions) and synaptic plasticity in the prefrontal cortex (PFC), little is known …
executive functions) and synaptic plasticity in the prefrontal cortex (PFC), little is known …
Calpain product of WT‐CRMP2 reduces the amount of surface NR2B NMDA receptor subunit
…, J Honnorat, J Glowinski, J Prémont… - Journal of …, 2006 - Wiley Online Library
The brain is particularly vulnerable to ischaemia; however, neurons can become tolerant to
ischaemic insult. This tolerance has been shown to involve activation of NMDA receptors, but …
ischaemic insult. This tolerance has been shown to involve activation of NMDA receptors, but …
Pyruvate and lactate protect striatal neurons against N‐methyl‐d‐aspartate‐induced neurotoxicity
…, M Israël, J Glowinski, J Prémont - European Journal of …, 1999 - Wiley Online Library
A sustained release of glutamate contributes to neuronal loss during cerebral ischaemia.
Using cultured mouse striatal neurons, we observed that glucose deprivation, which occurs in …
Using cultured mouse striatal neurons, we observed that glucose deprivation, which occurs in …