Pyruvate protects neurons against hydrogen peroxide-induced toxicity

S Desagher, J Glowinski, J Prémont - Journal of Neuroscience, 1997 - Soc Neuroscience
Hydrogen peroxide (H 2 O 2 ) is suspected to be involved in numerous brain pathologies such
as neurodegenerative diseases or in acute injury such as ischemia or trauma. In this study…

[HTML][HTML] Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

M Cazorla, J Prémont, A Mann, N Girard… - The Journal of …, 2011 - Am Soc Clin Investig
The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related
kinase B (TrkB) have emerged as key mediators in the pathophysiology of several mood …

Glutamate-dependent phosphorylation of elongation factor-2 and inhibition of protein synthesis in neurons

…, J Glowinski, AC Nairn, J Prémont - Journal of …, 1997 - Soc Neuroscience
Postischemic delayed neuronal death is attributed to excitotoxic activation of glutamate
receptors. It is preceded by a persistent inhibition of protein synthesis, the molecular basis of …

Sphingosine‐1‐phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades

A Pébay, M Toutant, J Prémont… - European Journal of …, 2001 - Wiley Online Library
Sphingosine‐1‐phosphate (S1P) is a potent lysophospholipid mediator mostly released by
activated platelets. It is involved in several functions in peripheral tissues, but its effects in the …

Increase in External Glutamate and NMDA Receptor Activation Contribute to H2O2‐Induced Neuronal Apoptosis

…, M Israël, J Glowinski, J Prémont - Journal of …, 1999 - Wiley Online Library
: The present study aims to investigate the role of extracellular glutamate and NMDA receptor
stimulation in the neuronal death induced by a transient exposure to H 2 O 2 of cultured …

Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain

…, J Glowinski, V Rogemond, J Prémont… - Journal of …, 2005 - Wiley Online Library
CRMP1, CRMP2, and CRMP5 have been identified as cytosolic proteins relaying semaphorin
3A signalling, one of the molecular cues conducting axon and dendrite growth and …

[HTML][HTML] Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice

…, C Rose, JP Guilloux, C Pilon, A Dranovsky, J Prémont - PloS one, 2010 - journals.plos.org
In the last decades, few mechanistically novel therapeutic agents have been developed to
treat mental and neurodegenerative disorders. Numerous studies suggest that targeting …

Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex

MS Kruse, J Prémont, MO Krebs, TM Jay - European …, 2009 - Elsevier
Despite the tremendous importance of D1 and NMDA receptors to cognition (working memory,
executive functions) and synaptic plasticity in the prefrontal cortex (PFC), little is known …

Calpain product of WT‐CRMP2 reduces the amount of surface NR2B NMDA receptor subunit

…, J Honnorat, J Glowinski, J Prémont… - Journal of …, 2006 - Wiley Online Library
The brain is particularly vulnerable to ischaemia; however, neurons can become tolerant to
ischaemic insult. This tolerance has been shown to involve activation of NMDA receptors, but …

Pyruvate and lactate protect striatal neurons against N‐methyl‐d‐aspartate‐induced neurotoxicity

…, M Israël, J Glowinski, J Prémont - European Journal of …, 1999 - Wiley Online Library
A sustained release of glutamate contributes to neuronal loss during cerebral ischaemia.
Using cultured mouse striatal neurons, we observed that glucose deprivation, which occurs in …