User profiles for J. Thundyil

John Thundyil

National Neuroscience Institute
Verified email at nni.com.sg
Cited by 2731

[HTML][HTML] Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

TM Woodruff, J Thundyil, SC Tang, CG Sobey… - Molecular …, 2011 - Springer
Stroke is the world's second leading cause of mortality, with a high incidence of severe
morbidity in surviving victims. There are currently relatively few treatment options available to …

Toll-like receptors in ischemia-reperfusion injury

TV Arumugam, E Okun, SC Tang, J Thundyil… - Shock, 2009 - journals.lww.com
Ischemia-reperfusion (I/R) injuries are implicated in a large array of pathological conditions
such as myocardial infarction, cerebral stroke, and hepatic, renal, and intestinal ischemia, as …

Adiponectin receptor signalling in the brain

J Thundyil, D Pavlovski, CG Sobey… - British journal of …, 2012 - Wiley Online Library
Adiponectin is an important adipocyte‐derived hormone that regulates metabolism of lipids
and glucose, and its receptors (AdipoR1, AdipoR2, T‐cadherin) appear to exert actions in …

[HTML][HTML] Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

…, C Bernreuther, M Glatzel, YL Cheng, J Thundyil… - Cell death & …, 2013 - nature.com
… slice were outlined and the area quantified (NIH Image J software). To correct for brain
swelling, … Quantification of protein levels was achieved by densitometry analysis using Image J

Mitochondrial dysfunction and Parkinson disease: a Parkin–AMPK alliance in neuroprotection

L Hang, J Thundyil, KL Lim - Annals of the New York Academy …, 2015 - Wiley Online Library
Although a subject of intense research, the etiology of Parkinson disease (PD) remains poorly
understood. However, a wide range of studies conducted over the past few decades have …

Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis

D Pavlovski, J Thundyil, PN Monk… - The FASEB …, 2012 - Wiley Online Library
C5a receptors are found in the central nervous system (CNS), on both neurons and glia.
However, the origin of the C5a, which activates these receptors, is unclear. In the present study, …

The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice

…, D Orozco, P Ludewig, J Thundyil… - Journal of Cerebral …, 2012 - journals.sagepub.com
The development of the brain tissue damage in ischemic stroke is composed of an immediate
component followed by an inflammatory response with secondary tissue damage after …

DAMPs and neurodegeneration

J Thundyil, KL Lim - Ageing research reviews, 2015 - Elsevier
The concept of neuroinflammation has come a full circle; from being initially regarded as a
controversial viewpoint to its present day acceptance as an integral component of …

Evidence that γ-secretase-mediated notch signaling induces neuronal cell death via the nuclear factor-κB-Bcl-2-interacting mediator of cell death pathway in ischemic …

…, S Yang, YK Yun, JS Park, DK Yang, J Thundyil… - Molecular …, 2011 - ASPET
Notch-1 (Notch) is a cell surface receptor that regulates cell-fate decisions in the developing
nervous system, and it may also have roles in synaptic plasticity in the adult brain. Binding …

[HTML][HTML] Evidence that the EphA2 receptor exacerbates ischemic brain injury

J Thundyil, S Manzanero, D Pavlovski, TR Cully… - PLoS …, 2013 - journals.plos.org
Ephrin (Eph) signaling within the central nervous system is known to modulate axon guidance,
synaptic plasticity, and to promote long-term potentiation. We investigated the potential …