… K d values were obtained from Figure 1 and reference 8 and compared with control K d
values for WT-CaM. CaM indicates calmodulin; CPVT, catecholaminergic polymorphic …

The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression
of heart failure and the antiarrhythmic action of dantrolene - Walweel - 2017 - Clinical …

Dantrolene is the first line therapy of malignant hyperthermia. Animal studies suggest that
dantrolene also protects against heart failure and arrhythmias caused by spontaneous Ca 2+ …

… In all failing hearts there was an increase in RyR2 activity at end-diastolic cytoplasmic Ca 2
+ (100 nM), a decreased cytoplasmic [Ca 2 + ] required for half maximal activation (K a ) and …

… Using FRET between donor-FKBP12.6 and acceptor-CaM bound to RyR2, we
determined that CaM binds to RyR2 from healthy human heart with a K d = 121 ± 14 nM. Ex-vivo …

Dantrolene is a neutral hydantoin that is clinically used as a skeletal muscle relaxant to
prevent overactivation of the skeletal muscle calcium release channel (RyR1) in response to …

… Addition of physiological levels (1 mM) of Mg 2+ raised the K a for cytoplasmic Ca 2+ to 30
µM (human and sheep) or 90 µM (rat) and raised the K a for luminal Ca 2+ to ∼1 mM in all …

… Author links open overlay panel Kafa Walweel a , Elizabeth Cheesman a b , Peter Molenaar
… Dr Kafa Walweel is supported by grant (ORF2023-05) from The Prince Charles Hospital …

Normal heart contraction and rhythm relies on the proper flow of calcium ions (Ca 2+ ) into
cardiac cells and between their intracellular organelles, and any disruption can lead to …

Background A lung transplant is the last resort treatment for many patients with advanced lung
disease. The majority of donated lungs come from donors following brain death (BD). The …