The striatum, which is the major component of the basal ganglia in the brain, is regulated in
part by dopaminergic input from the substantia nigra. Severe movement disorders result from …

DOPAMINE receptors belong to a large class of neurotransmitter and hormone receptors
that are linked to their signal transduction pathways through guanine nucleotide binding …

In order to clone the D1 dopamine receptor linked to adenylyl cyclase activation, the polymerase
chain reaction was used with highly degenerate primers to selectively amplify a cDNA …

Although equilibrium competitive radioligand binding studies are often used to characterize
hormone and neurotransmitter receptors, the kinetics of such experiments have not been …

[Arg8]vasopressin (AVP) stimulates adrenocorticotropic hormone release from the anterior
pituitary by acting on the V1b AVP receptor. This receptor can be distinguished from the …

We have used the polymerase chain reaction technique to selectively amplify guanine
nucleotide-binding regulatory protein (G protein)-coupled receptor cDNA sequences from rat …

We have investigated the in vivo efficacy of a systemic gene transfer method, which combines
a liposomal delivery system (DLS liposomes) with episomally replicative DNA plasmids to …

The expression of mRNAs coding for alpha 1, alpha 2, alpha 3, alpha 5, and alpha 6 subunits
of the GABAA neurotransmitter receptor was followed during the development of the rat …

Using the polymerase chain reaction technique with degenerative primers, we obtained
from a rat pituitary cDNA library a cDNA fragment, rAP236, that exhibited considerable …

We have characterized a new synthetic gene delivery system, termed DLS, which may be
suitable for systemic gene therapy. DLS constitutes a lipopolyamine and a neutral lipid and …