Protein–protein interactions are a crucial element in cellular function. The wealth of information
currently available on intracellular-signaling pathways has led many to appreciate the …

Signaling via G-protein-coupled receptors (GPCRs) is central for the function of biological
systems. Many clinically used drugs target GPCRs directly or target molecules involved in …

The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains
unclear despite an undisputed role of β-catenin. Using single-cell analysis, we identified a …

Regulators of G protein signaling (RGS) proteins are potent negative modulators of G
protein signaling and have been proposed as potential targets for small-molecule inhibitor …

The FZD4:LRP5:TSPAN12 receptor complex is activated by the secreted protein Norrin in
retinal endothelial cells and leads to βcatenin‐dependent formation of the blood–retina–…

Regulators of G-protein signaling (RGS) proteins are potent negative modulators of signal
transduction through G-protein-coupled receptors. They function by binding to activated (GTP-…

Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. EOC
is often diagnosed at late stages, with peritoneal metastases and ascites production. Current …

Secreted Wnt ligands play a major role in the development and progression of many cancers
by modulating signaling through cell-surface Frizzled receptors (FZDs). In order to achieve …

Many current therapies target G protein coupled receptors (GPCR), transporters, or ion
channels. In addition to directly targeting these proteins, disrupting the protein–protein …

Recently, regulators of G protein signaling (RGS) proteins have emerged as potential therapeutic
targets since they provide an alternative method of modulating the activity of G protein-…