User profiles for L. M. Kaminskas
Lisa KaminskasAssociate Professor of Pharmacology, The University of Queensland Verified email at uq.edu.au Cited by 6113 |
From sewer to saviour—targeting the lymphatic system to promote drug exposure and activity
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …
Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties
Dendrimers show increasing promise as drug-delivery vectors and can be generated with a
wide range of scaffold structures, sizes and surface functionalities. To this point, the majority …
wide range of scaffold structures, sizes and surface functionalities. To this point, the majority …
New developments in dry powder pulmonary vaccine delivery
Pulmonary immunization has gained increased recognition as a means of triggering both a
mucosal and systemic immune response without the use of needles. The appropriate …
mucosal and systemic immune response without the use of needles. The appropriate …
Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy
LM Kaminskas, VM McLeod, GM Ryan, BD Kelly… - Journal of Controlled …, 2014 - Elsevier
Direct administration of chemotherapeutic drugs to the lungs significantly enhances drug
exposure to lung resident cancers and may improve chemotherapy when compared to …
exposure to lung resident cancers and may improve chemotherapy when compared to …
A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery …
LM Kaminskas, VM McLeod, BD Kelly, G Sberna… - … , Biology and Medicine, 2012 - Elsevier
The pharmacokinetics, biodistribution, and antitumor efficacy of three doxorubicin formulations
(doxorubicin in saline, conjugated to a polylysine dendrimer, and encapsulated within a …
(doxorubicin in saline, conjugated to a polylysine dendrimer, and encapsulated within a …
The Impact of Molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly l-Lysine Dendrimers
LM Kaminskas, BJ Boyd, P Karellas… - Molecular …, 2008 - ACS Publications
The impact of PEGylation on the pharmacokinetics and biodistribution of 3 H-labeled poly l-lysine
dendrimers has been investigated after intravenous administration to rats. The …
dendrimers has been investigated after intravenous administration to rats. The …
Cationic Poly-l-lysine Dendrimers: Pharmacokinetics, Biodistribution, and Evidence for Metabolism and Bioresorption after Intravenous Administration to Rats
BJ Boyd, LM Kaminskas, P Karellas… - Molecular …, 2006 - ACS Publications
… Kaminskas. A comparison of the lung clearance kinetics of solid lipid nanoparticles and …
Kaminskas. Effect of increased surface hydrophobicity via drug conjugation on the clearance of …
Kaminskas. Effect of increased surface hydrophobicity via drug conjugation on the clearance of …
Pharmacokinetics and Tumor Disposition of PEGylated, Methotrexate Conjugated Poly-l-lysine Dendrimers
LM Kaminskas, BD Kelly, VM McLeod… - Molecular …, 2009 - ACS Publications
Dendrimers have potential for delivering chemotherapeutic drugs to solid tumors via the
enhanced permeation and retention (EPR) effect. The impact of conjugation of hydrophobic …
enhanced permeation and retention (EPR) effect. The impact of conjugation of hydrophobic …
The effect of amino acid excipients on morphology and solid-state properties of multi-component spray-dried formulations for pulmonary delivery of …
T Sou, LM Kaminskas, TH Nguyen, R Carlberg… - European Journal of …, 2013 - Elsevier
For a dry powder carrier platform to be suitable for pulmonary delivery of potent biomacromolecules,
it has to be aerosolisable and capable of stabilising the biomacromolecules. In the …
it has to be aerosolisable and capable of stabilising the biomacromolecules. In the …
Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation
Cancer is a leading cause of death within developed nations, and part of this morbidity is
due to difficulties associated with its treatment. Currently, anticancer therapy relies heavily …
due to difficulties associated with its treatment. Currently, anticancer therapy relies heavily …