User profiles for M. G. CARON
 | Marc G. CaronJames B. Duke Professor, Cell Biology, Medicine, Neurobiology Duke University Verified email at duke.edu Cited by 145644 |
Dopamine receptors: from structure to function
… CARON … CARON … Caron. Dopamine Receptors: From Structure to Function. Physiol. …
Turning off the signal: desensitization of β‐adrenergic receptor function
WP Hausdorff, MG Caron, RJ Lefkowitz - The FASEB Journal, 1990 - Wiley Online Library
… levels of Mg" in the membrane assays of AC activity proved to be crucial in revealing the
effects of PKA on the desensitization process (14). Because cytosolic levels of Mg" have been …
effects of PKA on the desensitization process (14). Because cytosolic levels of Mg" have been …
Model systems for the study of seven-transmembrane-segment receptors
The past few years have been an exciting period in the field of receptor biology as remarkable
similarities among various signal transduction systems have been revealed. Many such …
similarities among various signal transduction systems have been revealed. Many such …
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
… We found that intraperitoneal injections of high doses of cocaine ( 40 mg per kg) and o-amphetamine
(10 mg per kg) produced no significant locomotor effects (Fig. 3c) or stereotyped …
(10 mg per kg) produced no significant locomotor effects (Fig. 3c) or stereotyped …
β-Arrestin-Dependent Formation of β2 Adrenergic Receptor-Src Protein Kinase Complexes
…, FT Lin, H Kawakatsu, K Owada, DK Luttrell, MG Caron… - Science, 1999 - science.org
The Ras-dependent activation of mitogen-activated protein (MAP) kinase pathways by
many receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) …
many receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) …
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
…, RE Diehl, RA Mumford, EE Slater, IS Sigal, MG Caron… - Nature, 1986 - nature.com
… Approximately 100 mg offusion protein of 90% purity was obtained from 1 litre of starting
culture. Antibodies were detected in serum from injected rabbits by incubation of the serum with "…
culture. Antibodies were detected in serum from injected rabbits by incubation of the serum with "…
β-Arrestin: a protein that regulates β-adrenergic receptor function
Homologous or agonist-specific desensitization of β-adrenergic receptors is thought to be
mediated by a specific kinase, the β-adrenergic receptor kinase (βARK). However, recent data …
mediated by a specific kinase, the β-adrenergic receptor kinase (βARK). However, recent data …
Enhanced morphine analgesia in mice lacking β-arrestin 2
… (1 mg/kg sc); at this time point, animals were injected with morphine (4 mg/kg sc) for a cumulative
dose of 5 mg/kg… with morphine (5 mg/kg sc) to yield a final cumulative dose of 10 mg/kg. …
dose of 5 mg/kg… with morphine (5 mg/kg sc) to yield a final cumulative dose of 10 mg/kg. …
Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
…, AM Colapietro, LS Barak, L Ménard, MG Caron - Science, 1996 - science.org
β-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G
protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by …
protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by …
[HTML][HTML] Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
… The B max is 0.12 pmol/mg for the Nr1neo −/− and 1.2 pmol/mg for wild-type mice (n = 3 for
… Wild-type mice injected with 3 mg/kg PCP or 0.2 mg/kg MK-801 demonstrated a pattern of …
… Wild-type mice injected with 3 mg/kg PCP or 0.2 mg/kg MK-801 demonstrated a pattern of …