… Fairbairn & MS Denison, manuscript in preparation). This significant difference in biological
… less potent in mammalian cells (DH Han & MS Denison, unpublished results). The principal …

The Ah receptor (AhR) is a ligand-dependent transcription factor that mediates a wide range
of biological and toxicological effects that result from exposure to a structurally diverse …

The Ah receptor (AhR) is a ligand-dependent transcription factor that can be activated by
structurally diverse synthetic and naturally-occurring chemicals. Although a significant amount …

Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC)
transplants remains limited by the ability to expand these cells ex vivo. An unbiased …

Disease tolerance is the ability of the host to reduce the effect of infection on host fitness.
Analysis of disease tolerance pathways could provide new approaches for treating infections …

The environmental contaminant 2,3,7,8-tetra-chlorodibenzo-p-dioxin produces its biological
effects by binding to an intracellular protein (the Ah receptor). The dioxin-Ah receptor …

Exposure to specific polychlorinated diaromatic hydrocarbons (PCDH), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD, dioxin), produces a wide variety of species- and tissue-…

The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated
and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants …

This study demonstrates that the novelin vitroCALUX (chemical-activated luciferase
expression) assay is a rapid, sensitive assay for assessing the toxic potency of (mixtures of) aryl …

Background Concerns have been raised about the biological and toxicologic effects of the
antimicrobials triclocarban (TCC) and triclosan (TCS) in personal care products. Few studies …