Mechanisms underlying activation of soluble guanylate cyclase by the nitroxyl donor Angeli's salt
A Zeller, MV Wenzl, M Beretta, H Stessel… - Molecular …, 2009 - ASPET
Nitroxyl (HNO) may be formed endogenously by uncoupled nitric-oxide (NO) synthases,
enzymatic reduction of NO or as product of vascular nitroglycerin bioactivation. The established …
enzymatic reduction of NO or as product of vascular nitroglycerin bioactivation. The established …
[HTML][HTML] Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1
M Beretta, ACF Gorren, MV Wenzl, R Weis… - Journal of biological …, 2010 - ASBMB
The East Asian variant of mitochondrial aldehyde dehydrogenase (ALDH2) exhibits significantly
reduced dehydrogenase, esterase, and nitroglycerin (GTN) denitrating activities. The …
reduced dehydrogenase, esterase, and nitroglycerin (GTN) denitrating activities. The …
[HTML][HTML] Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry
BS Lang, ACF Gorren, G Oberdorfer, MV Wenzl… - Journal of Biological …, 2012 - ASBMB
Aldehyde dehydrogenase-2 (ALDH2) catalyzes the bioactivation of nitroglycerin (glyceryl
trinitrate, GTN) in blood vessels, resulting in vasodilation by nitric oxide (NO) or a related …
trinitrate, GTN) in blood vessels, resulting in vasodilation by nitric oxide (NO) or a related …
[HTML][HTML] Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2
MV Wenzl, M Beretta, ACF Gorren, A Zeller… - Journal of biological …, 2009 - ASBMB
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) plays an essential role in nitroglycerin (GTN)
bioactivation, resulting in formation of NO or a related activator of soluble guanylate …
bioactivation, resulting in formation of NO or a related activator of soluble guanylate …
Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation
MV Wenzl, M Beretta, M Griesberger, M Russwurm… - Molecular …, 2011 - ASPET
To elucidate the mechanism underlying reduction of nitroglycerin (GTN) to nitric oxide (NO)
by mitochondrial aldehyde dehydrogenase (ALDH2), we generated mutants of the enzyme …
by mitochondrial aldehyde dehydrogenase (ALDH2), we generated mutants of the enzyme …
Vascular tolerance to nitroglycerin in ascorbate deficiency
G Wölkart, MV Wenzl, M Beretta, H Stessel… - Cardiovascular …, 2008 - academic.oup.com
Aims Nitroglycerin (GTN) acts through release of a nitric oxide (NO)-related activator of
soluble guanylate cyclase in vascular smooth muscle. Besides enzymatic GTN bioactivation …
soluble guanylate cyclase in vascular smooth muscle. Besides enzymatic GTN bioactivation …
Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase‐catalysed bioactivation of nitroglycerin
MV Wenzl, G Wölkart, H Stessel… - British journal of …, 2009 - Wiley Online Library
Background and purpose: Vascular tolerance to nitroglycerin (GTN) may be caused by
impaired GTN bioactivation due to inactivation of mitochondrial aldehyde dehydrogenase (ALDH2…
impaired GTN bioactivation due to inactivation of mitochondrial aldehyde dehydrogenase (ALDH2…
Tolerance to nitroglycerin through proteasomal down‐regulation of aldehyde dehydrogenase‐2 in a genetic mouse model of ascorbate deficiency
G Wölkart, M Beretta, MV Wenzl… - British Journal of …, 2013 - Wiley Online Library
Background and Purpose L ‐gulonolactone oxidase‐deficient ( G ulo (‐/‐) ) mice were used
to study the effects of ascorbate deficiency on aortic relaxation by nitroglycerin ( GTN ) with …
to study the effects of ascorbate deficiency on aortic relaxation by nitroglycerin ( GTN ) with …
Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase
M Griesberger, A Kollau, G Wölkart, MV Wenzl… - Molecular …, 2011 - ASPET
Mitochondrial aldehyde dehydrogenase (ALDH2) contributes to vascular bioactivation of
the antianginal drugs nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN), resulting in …
the antianginal drugs nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN), resulting in …
Role of the general base Glu268 in nitroglycerin bioactivation and mechanism-based superoxide formation by aldehyde dehydrogenase-2
MV Wenzl, M Beretta, ACF Gorren, PK Baral… - BMC …, 2009 - Springer
Background Mitochondrial aldehyde dehydrogenase (ALDH2) plays an essential role in
nitroglycerin (GTN) bioactivation, resulting in formation of nitric oxide (NO) or a related activator …
nitroglycerin (GTN) bioactivation, resulting in formation of nitric oxide (NO) or a related activator …