… Ewen MacDonald, Brian Kobilka and Mika Scheinin describe how these mice may be
utilized to elucidate the physiological functions of the receptor subtypes and the properties of …

1. The pharmacodynamic effects of medetomidine, a novel alpha 2-adrenoceptor agonist,
are reviewed. 2. In receptor binding experiments, and in isolated organ preparations …

The α 2A ‐adrenoceptor has been identified as an important regulator of blood glucose
homeostasis. α 2A ‐Adrenoceptors on pancreatic β‐cells inhibit insulin secretion, and α 2A ‐…

Relationships of impulsive and nonimpulsive violent behavior to cerebrospinal fluid (CSF)
monoamines and their metabolite concentrations were studied in thirty-six violent offenders. A …

We investigated the metabolism of human brown adipose tissue (BAT) in healthy subjects
by determining its cold-induced and insulin-stimulated glucose uptake and blood flow (…

The effects of the new, highly selective alpha 2 -adrenergic agonist, dexmedetomidine,
were studied in a randomized, placebo-controlled, double-blind trial in 24 ASA I patients. …

α 2 -Adrenergic receptors in brain are important presynaptic modulators of central noradrenergic
function (autoreceptors) and postsynaptic mediators of many of the widespread effects …

Background: Dexmedetomidine, a selective α 2 ‐adrenoceptor agonist, induces a unique,
sleep‐like state of sedation. The objective of the present work was to study human …

The effects of dexmedetomidine, an alpha 2-adrenoceptor agonist, on vigilance, thiopental
anesthetic requirements, and the hemodynamic, catecholamine, and hormonal responses to …

Background: Patients with mild cognitive impairment (MCI) have increased risk to develop
Alzheimer disease (AD). In AD increased brain amyloid burden has been demonstrated in …