User profiles for P. M. Sexton
 | Patrick SextonMonash University Verified email at monash.edu Cited by 31120 |
Functional selectivity and classical concepts of quantitative pharmacology
The concept of intrinsic efficacy has been enshrined in pharmacology for half of a century, yet
recent data have revealed that many ligands can differentially activate signaling pathways …
recent data have revealed that many ligands can differentially activate signaling pathways …
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related
peptides (CGRPs), and adrenomedullin. The first calcitonin receptor was cloned in 1991. Its …
peptides (CGRPs), and adrenomedullin. The first calcitonin receptor was cloned in 1991. Its …
Allosteric modulation of G protein–coupled receptors
The past decade has witnessed a significant growth in the identification of allosteric modulators
of G protein–coupled receptors (GPCRs), ie, ligands that interact with binding sites that …
of G protein–coupled receptors (GPCRs), ie, ligands that interact with binding sites that …
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Despite recent advances in crystallography and the availability of G-protein-coupled receptor
(GPCR) structures, little is known about the mechanism of their activation process, as only …
(GPCR) structures, little is known about the mechanism of their activation process, as only …
Mechanisms of signalling and biased agonism in G protein-coupled receptors
G protein-coupled receptors (GPCRs) are the largest group of cell surface receptors in
humans that signal in response to diverse inputs and regulate a plethora of cellular processes. …
humans that signal in response to diverse inputs and regulate a plethora of cellular processes. …
Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product
… buffer [DMEM containing 0.1% (w/v) BSA] with ∼80 pM 125 I-labeled salmon CT or ∼70
pM 125 I-labeled rat amylin (Sexton et al., 1993), in the absence (total binding) or presence of …
pM 125 I-labeled rat amylin (Sexton et al., 1993), in the absence (total binding) or presence of …
G-protein–coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor
…, CF Sanchez-Ferrer, S Heringer-Walther, PM Sexton… - Circulation, 2005 - Am Heart Assoc
Background— We previously identified the G-protein–coupled receptor Mas, encoded by
the Mas proto-oncogene, as an endogenous receptor for the heptapeptide angiotensin-(1-7); …
the Mas proto-oncogene, as an endogenous receptor for the heptapeptide angiotensin-(1-7); …
Emerging paradigms in GPCR allostery: implications for drug discovery
Allosteric ligands bind to G protein-coupled receptors (GPCRs; also known as seven-transmembrane
receptors) at sites that are distinct from the sites to which endogenous ligands bind…
receptors) at sites that are distinct from the sites to which endogenous ligands bind…
Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.
GC Nicholson, JM Moseley, PM Sexton… - The Journal of …, 1986 - Am Soc Clin Investig
Calcitonin receptors have been characterized for the first time in isolated osteoclasts. These
receptors have been demonstrated by autoradiographic and biochemical methods, and the …
receptors have been demonstrated by autoradiographic and biochemical methods, and the …
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases,
such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length …
such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length …