[HTML][HTML] Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein …
E Butt, M Bernhardt, A Smolenski, P Kotsonis… - Journal of Biological …, 2000 - ASBMB
Endothelial nitric-oxide synthase (NOS-III) is defined as being strictly dependent on Ca 2+ /calmodulin
(CaM) for activity, although NO release from endothelial cells has been reported …
(CaM) for activity, although NO release from endothelial cells has been reported …
Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction
…, C De Felipe, S Hunt, J Kabir, P Kotsonis… - Circulation …, 2004 - Am Heart Assoc
… In addition, this C-fiber dependency is likely related to neuropeptide substance P release
and activity because blockade of tachykinin NK 1 receptors (66.3±13.7% inhibition, n=6; P<…
and activity because blockade of tachykinin NK 1 receptors (66.3±13.7% inhibition, n=6; P<…
… 1H-[1, 2, 4] oxadiazolo [4, 3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in …
M Feelisch, P Kotsonis, J Siebe, B Clement… - Molecular …, 1999 - ASPET
Soluble guanylyl cyclase (sGC) is an important effector for nitric oxide (NO). It acts by
increasing intracellular cyclic GMP (cGMP) levels to mediate numerous biological functions. …
increasing intracellular cyclic GMP (cGMP) levels to mediate numerous biological functions. …
Role of pH as a regulator of vaginal physiological environment
GB Melis, MT Ibba, B Steri, P Kotsonis, V Matta… - Minerva …, 2000 - europepmc.org
In the vagina there are several microorganisms. Their survival is fundamental to have a
physiological environment in the vagina (ecosystem). The same vaginal environment playg a …
physiological environment in the vagina (ecosystem). The same vaginal environment playg a …
Cloning and functional characterization of the guinea pig vanilloid receptor 1
…, J Winter, P Kotsonis, H Rang, P McIntyre - …, 2002 - Elsevier
We have cloned a guinea pig Vanilloid receptor 1 (VR1) from a dorsal root ganglion cDNA
library and expressed it in CHO cells. The receptor has been functionally characterized by …
library and expressed it in CHO cells. The receptor has been functionally characterized by …
[HTML][HTML] Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase
A Reif, LG Fröhlich, P Kotsonis, A Frey… - Journal of Biological …, 1999 - ASBMB
The biosynthesis of nitric oxide (NO) is catalyzed by homodimeric NO synthases (NOS). For
unknown reasons, all NOS co-purify with substoichiometric amounts of (6 R)-5,6,7,8-…
unknown reasons, all NOS co-purify with substoichiometric amounts of (6 R)-5,6,7,8-…
Inhibition of Neuronal Nitric Oxide Synthase by 4-Amino Pteridine Derivatives: Structure−Activity Relationship of Antagonists of (6R)-5,6,7,8-Tetrahydrobiopterin …
LG Fröhlich, P Kotsonis, H Traub… - Journal of medicinal …, 1999 - ACS Publications
… Another synthetic approach involved using initially 2,6-diamino-4-chloro-5-p-chlorophenylazopyrimidine
12 44 which was prepared from p-chloroaniline 10 by diazotation and …
12 44 which was prepared from p-chloroaniline 10 by diazotation and …
[HTML][HTML] Microenvironmental M1 tumor-associated macrophage polarization influences cancer-related anemia in advanced ovarian cancer: key role of interleukin-6
C Madeddu, G Gramignano, P Kotsonis, F Coghe… - …, 2018 - ncbi.nlm.nih.gov
… that released by non-stimulated cells (P=0.0005 for IL-6, and P=0.014 for hepcidin) (Online …
significantly lower than those found in TAM cultures (P<0.001 for both). These results support …
significantly lower than those found in TAM cultures (P<0.001 for both). These results support …
Surgical outcome and complications of total laparoscopic hysterectomy for very large myomatous uteri in relation to uterine weight: a prospective study in a continuous …
A Macciò, G Chiappe, P Kotsonis, R Nieddu… - Archives of gynecology …, 2016 - Springer
… The mean operative time varied by uterine weight, with the longest duration in patients
with the largest uteri (p < 0.001, Table 2). The largest uteri and those deformed by multiple …
with the largest uteri (p < 0.001, Table 2). The largest uteri and those deformed by multiple …
Genome size variations within Dasypyrum villosum: correlations with chromosomal traits, environmental factors and plant phenotypic characteristics and behaviour in …
…, C De Pace, GTS Mugnozza, P Kotsonis… - Theoretical and Applied …, 1998 - Springer
Feulgen/DNA cytophotometric determinations carried out in the root meristem of seedlings
showed that substantial quantitative alterations in the nuclear genome are present between …
showed that substantial quantitative alterations in the nuclear genome are present between …