Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity

VA Doze, RS Papay, BL Goldenstein, MK Gupta… - Molecular …, 2011 - ASPET
The role of α 1 -adrenergic receptors (α 1 ARs) in cognition and mood is controversial, probably
as a result of past use of nonselective agents. α 1A AR activation was recently shown to …

α1-Adrenergic receptor stimulates interleukin-6 expression and secretion through both mRNA stability and transcriptional regulation: involvement of p38 mitogen …

DM Perez, RS Papay, T Shi - Molecular pharmacology, 2009 - ASPET
Our previous studies have demonstrated that activation of α 1 -adrenergic receptors (ARs)
increased interleukin-6 (IL-6) mRNA expression and protein secretion, which is probably an …

α1-Adrenergic receptors regulate neurogenesis and gliogenesis

MK Gupta, RS Papay, CWD Jurgens, RJ Gaivin… - Molecular …, 2009 - ASPET
The understanding of the function of α 1 -adrenergic receptors in the brain has been limited
due to a lack of specific ligands and antibodies. We circumvented this problem by using …

α1A- but not α1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism

…, SA Ross, RJ Gaivin, RS Papay… - Cardiovascular …, 2005 - academic.oup.com
Objective: Brief periods of ischemia stimulate an endogenous mechanism in the heart that
protects the myocardium from subsequent ischemic injury. α 1 -Adrenergic receptors (ARs) …

α1A-Adrenergic receptor prevents cardiac ischemic damage through PKCδ/GLUT1/4-mediated glucose uptake

T Shi, RS Papay, DM Perez - Journal of Receptors and Signal …, 2016 - Taylor & Francis
While α 1 -adrenergic receptors (ARs) have been previously shown to limit ischemic cardiac
damage, the mechanisms remain unclear. Most previous studies utilized low oxygen …

Site-specific proteoglycan characteristics of third carpal articular cartilage in exercised and nonexercised horses

…, CJ Malemud, BG Carter, RS Papay… - American Journal of …, 1995 - Am Vet Med Assoc
The relevance of site and the influence of exercise on third carpal articular cartilage proteoglycan
( pg ) were assessed in 16 horses. Six horses were exercised (exercised group) for 30 …

The role of α1-adrenergic receptors in regulating metabolism: increased glucose tolerance, leptin secretion and lipid oxidation

T Shi, RS Papay, DM Perez - Journal of Receptors and Signal …, 2017 - Taylor & Francis
The role of α 1 -adrenergic receptors (α 1 -ARs) and their subtypes in metabolism is not well
known. Most previous studies were performed before the advent of transgenic mouse …

Gene expression profile of neurodegeneration induced by α1B‐adrenergic receptor overactivity: NMDA/GABAA dysregulation and apoptosis

J Yun, RJ Gaivin, DF McCune, A Boongird, RS Papay… - Brain, 2003 - academic.oup.com
The α 1 ‐adrenergic receptors (α 1 ARs) play an important role in mediating sympathetic
neurotransmission in peripheral organ systems; however, central α 1 ARs are not well …

Pathologic and metabolic responses of experimental osteoarthritis to estradiol and an estradiol antagonist.

…, VM GOLDBERG, RS PAPAY… - … Research (1976-2007 …, 1982 - journals.lww.com
Clinical and experimental evidence suggests that endogenous and, possibly, exogenous sex
hormones may influence the development of osteoarthritic lesions. Clinically, an increased …

Long-term α1B-adrenergic receptor activation shortens lifespan, while α1A-adrenergic receptor stimulation prolongs lifespan in association with decreased cancer …

KM Collette, XD Zhou, HM Amoth, MJ Lyons, RS Papay… - Age, 2014 - Springer
The α 1 -adrenergic receptor (α 1 AR) subtypes, α 1A AR and α 1B AR, have differential
effects in the heart and central nervous system. Long-term stimulation of the α 1A AR subtype …