User profiles for R. Zent

Roy Zent

vanderbilt
Verified email at vanderbilt.edu
Cited by 12874

The tail of integrins, talin, and kindlins

M Moser, KR Legate, R Zent, R Fässler - Science, 2009 - science.org
Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …

[HTML][HTML] Progression of chronic kidney disease: too much cellular talk causes damage

L Gewin, R Zent, A Pozzi - Kidney international, 2017 - Elsevier
Tubulointerstitial fibrosis, tubular atrophy, and peritubular capillary rarefaction are major
hallmarks of chronic kidney disease. The tubulointerstitium consists of multiple cell components …

Integrins in kidney disease

A Pozzi, R Zent - Journal of the American Society of Nephrology, 2013 - journals.lww.com
A major hallmark of chronic kidney injury is fibrosis, which is characterized by increased
accumulation of extracellular matrix components that replace the damaged tissue. Normally, the …

[HTML][HTML] The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation

DA Calderwood, R Zent, R Grant, DJG Rees… - Journal of Biological …, 1999 - ASBMB
The β subunit cytoplasmic domains of integrin adhesion receptors are necessary for the
connection of these receptors to the actin cytoskeleton. The cytoplasmic protein, talin, binds to β …

Kindlin-2 controls bidirectional signaling of integrins

…, M Bösl, R Zent, M Moser, R Fässler - Genes & …, 2008 - genesdev.cshlp.org
Control of integrin activation is required for cell adhesion and ligand-induced signaling.
Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-…

[HTML][HTML] Integrin β1 signaling is necessary for transforming growth factor-β activation of p38MAPK and epithelial plasticity

NA Bhowmick, R Zent, M Ghiassi, M McDonnell… - Journal of Biological …, 2001 - ASBMB
Transforming growth factor-β (TGF-β) can induce epithelial to mesenchymal transdifferentiation
(EMT) in mammary epithelial cells. TGF-β-meditated EMT involves the stimulation of a …

[HTML][HTML] Sirt1 activation protects the mouse renal medulla from oxidative injury

…, H Fan, HC Yang, AB Fogo, R Zent… - The Journal of …, 2010 - Am Soc Clin Investig
R. Zent is recipient of NIH grants DK075594 and DK65123, an American Heart Association
established investigator award, and a merit award from the Department of Veterans Affairs. L. …

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

…, C Kluger, C Klingner, B Sabass, R Zent… - Nature cell …, 2015 - nature.com
The ability of cells to adhere and sense differences in tissue stiffness is crucial for organ
development and function. The central mechanisms by which adherent cells detect extracellular …

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

…, A Lambacher, K Austen, DJ Müller, R Zent, R Fässler - Elife, 2016 - elifesciences.org
10.7554/eLife.10130.001 Integrins require an activation step prior to ligand binding and
signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly …

[HTML][HTML] Vinculin controls talin engagement with the actomyosin machinery

…, E Meiler-Rodriguez, P Wang, N Bate, R Zent… - Nature …, 2015 - nature.com
The link between extracellular-matrix-bound integrins and intracellular F-actin is essential
for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin …