User profiles for R. Zent
Roy Zentvanderbilt Verified email at vanderbilt.edu Cited by 12874 |
The tail of integrins, talin, and kindlins
M Moser, KR Legate, R Zent, R Fässler - Science, 2009 - science.org
Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …
[HTML][HTML] Progression of chronic kidney disease: too much cellular talk causes damage
Tubulointerstitial fibrosis, tubular atrophy, and peritubular capillary rarefaction are major
hallmarks of chronic kidney disease. The tubulointerstitium consists of multiple cell components …
hallmarks of chronic kidney disease. The tubulointerstitium consists of multiple cell components …
Integrins in kidney disease
A Pozzi, R Zent - Journal of the American Society of Nephrology, 2013 - journals.lww.com
A major hallmark of chronic kidney injury is fibrosis, which is characterized by increased
accumulation of extracellular matrix components that replace the damaged tissue. Normally, the …
accumulation of extracellular matrix components that replace the damaged tissue. Normally, the …
[HTML][HTML] The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation
The β subunit cytoplasmic domains of integrin adhesion receptors are necessary for the
connection of these receptors to the actin cytoskeleton. The cytoplasmic protein, talin, binds to β …
connection of these receptors to the actin cytoskeleton. The cytoplasmic protein, talin, binds to β …
Kindlin-2 controls bidirectional signaling of integrins
…, M Bösl, R Zent, M Moser, R Fässler - Genes & …, 2008 - genesdev.cshlp.org
Control of integrin activation is required for cell adhesion and ligand-induced signaling.
Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-…
Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-…
[HTML][HTML] Integrin β1 signaling is necessary for transforming growth factor-β activation of p38MAPK and epithelial plasticity
NA Bhowmick, R Zent, M Ghiassi, M McDonnell… - Journal of Biological …, 2001 - ASBMB
Transforming growth factor-β (TGF-β) can induce epithelial to mesenchymal transdifferentiation
(EMT) in mammary epithelial cells. TGF-β-meditated EMT involves the stimulation of a …
(EMT) in mammary epithelial cells. TGF-β-meditated EMT involves the stimulation of a …
[HTML][HTML] Sirt1 activation protects the mouse renal medulla from oxidative injury
… R. Zent is recipient of NIH grants DK075594 and DK65123, an American Heart Association
established investigator award, and a merit award from the Department of Veterans Affairs. L. …
established investigator award, and a merit award from the Department of Veterans Affairs. L. …
Extracellular rigidity sensing by talin isoform-specific mechanical linkages
The ability of cells to adhere and sense differences in tissue stiffness is crucial for organ
development and function. The central mechanisms by which adherent cells detect extracellular …
development and function. The central mechanisms by which adherent cells detect extracellular …
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
10.7554/eLife.10130.001 Integrins require an activation step prior to ligand binding and
signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly …
signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly …
[HTML][HTML] Vinculin controls talin engagement with the actomyosin machinery
…, E Meiler-Rodriguez, P Wang, N Bate, R Zent… - Nature …, 2015 - nature.com
The link between extracellular-matrix-bound integrins and intracellular F-actin is essential
for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin …
for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin …