Activation of store-operated channels (SOCs) and capacitative calcium influx are triggered by
depletion of intracellular calcium stores. However, the exact molecular mechanism of such …

Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic
augmentation of Ca V 1.2 voltage-gated calcium channels 1 , 2 , 3 – 4 . However, this …

Voltage-dependent Ca 2+ channel function (Ca v 1.2, L-type Ca 2+ channel) is required for
cardiac excitation-contraction (EC) coupling. Ca v 1.2 plays a key role in modulating cardiac …

Voltage-dependent Ca 2+ channel (Ca v 1.2, L-type Ca 2+ channel) function is highly regulated
by hormones and neurotransmitters in large part through the activation of kinases and …

Increased sodium influx via incomplete inactivation of the major cardiac sodium channel Na
V 1.5 is correlated with an increased incidence of atrial fibrillation (AF) in humans. Here, we …

Rationale: Changing activity of cardiac Ca V 1.2 channels under basal conditions, during
sympathetic activation, and in heart failure is a major determinant of cardiac physiology and …

Store-operated cation (SOC) channels and capacitative Ca 2+ entry (CCE) play very important
role in cellular function, but the mechanism of their activation remains one of the most …

Cardiac tissue expresses several TRP proteins as well as a Mg 2+ ‐inhibited, non‐selective
cation current (I MIC ) that bears many characteristics of TRP channel currents. We used the …

Ca 2+ channel β-subunit interactions with pore-forming α-subunits are long-thought to be
obligatory for channel trafficking to the cell surface and for tuning of basal biophysical …

In a wide variety of cell types, including neurons and smooth muscle cells, activation of the
large-conductance voltage- and Ca 2+ -activated K + (BK) channels causes transient …