User profiles for S. LeFrancois

Simon Lefrancois

- Verified email at umontreal.ca - Cited by 2117

Stephane Lefrancois

- Verified email at inrs.ca - Cited by 2115

Theano: A Python framework for fast computation of mathematical expressions

…, C Laurent, S Lee, S Lefrancois, S Lemieux… - arXiv e …, 2016 - ui.adsabs.harvard.edu
Theano is a Python library that allows to define, optimize, and evaluate mathematical expressions
involving multi-dimensional arrays efficiently. Since its introduction, it has been one of …

Theano: A Python framework for fast computation of mathematical expressions

…, C Laurent, S Lee, S Lefrancois, S Lemieux… - arXiv preprint arXiv …, 2016 - arxiv.org
Theano is a Python library that allows to define, optimize, and evaluate mathematical expressions
involving multi-dimensional arrays efficiently. Since its introduction, it has been one of …

[HTML][HTML] The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin

S Lefrancois, J Zeng, AJ Hassan, M Canuel… - The EMBO …, 2003 - embopress.org
… To determine the fate of activator proteins after sortilin inhibition, COS‐7 were targeted with
the siRNA 1 construct, pulsed with [ 35 S]methionine/cysteine and chased with Dulbecco's …

[HTML][HTML] The nemertine toxin anabaseine and its derivative DMXBA (GTS-21): Chemical and pharmacological properties

W Kem, F Soti, K Wildeboer, S LeFrancois… - Marine Drugs, 2006 - mdpi.com
… Two decades ago a drastic decrease in AChRs was first reported in Alzheimer’s patients
and some Parkinson’s patients [92]. This finding stimulated considerable academic and …

[HTML][HTML] Autophagy in the neuronal ceroid lipofuscinoses (Batten disease)

…, A Thanabalasingam, S Lefrancois… - Frontiers in Cell and …, 2022 - frontiersin.org
… Furthermore, the loss of PPT1 in humans causes elevated S-palmitoylation along with
reduced endo-lysosomal localization of RAB7. These data suggest that the function of PPT1 is …

[HTML][HTML] A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis

…, JB Xu, JE Palmer, HL Best, S Lefrancois… - Cellular and Molecular …, 2021 - Springer
… , Alzheimer’s disease and Parkinson’s disease, possibly facilitating the pathogenic
mechanisms underlying these diseases [11,12,13]. Understanding the long-elusive function(s) of …

Effects of chronic renal failure on kidney drug transporters and cytochrome P450 in rats

…, MJ Hébert, M Roger, S Lefrancois… - Drug metabolism and …, 2011 - ASPET
… Samples were then sonicated on ice for 10 s to ensure homogeneity. Protein concentration
was determined using the method of Lowry et al. (1951), using bovine serum albumin as a …

Scaling of dissipative soliton fiber lasers to megawatt peak powers by use of large-area photonic crystal fiber

S Lefrançois, K Kieu, Y Deng, JD Kafka, FW Wise - Optics letters, 2010 - opg.optica.org
We report an all-normal dispersion femtosecond laser based on large-mode-area Yb-doped
photonic crystal fiber. Self-starting mode-locked pulses are obtained with an average power …

AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes

M Canuel, S Lefrancois, J Zeng, CR Morales - Biochemical and biophysical …, 2008 - Elsevier
… The cells were pulse-labeled for 30 min in medium supplemented with 1023 μCi/ml [ 35 S]
methionine (Amersham Biosciences). The chase was carried out using DMEM with 10% fetal …

Effects of chronic renal failure on liver drug transporters

J Naud, J Michaud, FA Leblond, S Lefrancois… - Drug metabolism and …, 2008 - ASPET
… Samples were then sonicated on ice for 10 s and filtered across a 5-μm membrane (PALL,
St… , Canada) with 30-s incubation at 94C, 30-s incubation at 60C, and 30-s incubation at 72C. …