OSTEOCLASTS, which are present only in bone, are multinucleated giant cells with the
capacity to resorb mineralized tissues. During the past decade, several new approaches have …

The strength and integrity of our bones depends on maintaining a delicate balance between
bone resorption by osteoclasts and bone formation by osteoblasts. As we age or as a result …

Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the
molecular basis for this is unknown. Here, we report a critical role for the osteoclastic estrogen …

We developed a co-culture system with mouse spleen cells and osteoblastic cells to examine
the role of osteoblasts in osteoclast formation. When mouse spleen cells and osteoblastic …

IL-17 is a newly discovered T cell–derived cytokine whose role in osteoclast development has
not been fully elucidated. Treatment of cocultures of mouse hemopoietic cells and primary …

… Hattersley G, Chambers TJ 1989 Calcitonin receptors as markers for osteoclastic differentiation:
… Rodan GA, Martin TJ 1981 Role of osteoblasts in hormonal control of bone resorption. A …

Osteoclast differentiation factor (ODF, also called RANKL/TRANCE/OPGL) stimulates the
differentiation of osteoclast progenitors of the monocyte/macrophage lineage into osteoclasts in …

Humoral hypercalcemia of malignancy is a common complication of lung and certain other
cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney. We …

We previously reported that osteoclast-like cells were formed in cocultures of a mouse
marrow-derived stromal cell line (ST2) with mouse spleen cells in the presence of 1 alpha, 25-…

The World Health Organization has established a task force charged with the mission of
developing a worldwide strategy for osteoporosis management and prevention. A direct …