It is well known that histone acetylases are important chromatin modifiers and that they play
a central role in chromatin transcription. Here, we present evidence for novel roles of histone …

… The average fluorescence intensity in the bleached region at each time point (I t ) was
measured in a region corresponding to at least 30% of the bleached region. For each time point, …

The transcription repressor Bach1 is a sensor and effector of heme that regulates the
expression of heme oxygenase 1 and globin genes. Heme binds to Bach1, inhibiting its DNA …

… INDY effectively reversed the aberrant tau-phosphorylation and rescued the repressed NFAT
(nuclear factor of activated T cell) signalling induced by Dyrk1A overexpression. Importantly…

… USP21 also associates with RNA polII in hepatocytes (T. Nakagawa and T. Ito, unpubl.). Thus,
it … We thank James T. Kadonaga for helpful discussions and advice. We are grateful to W. …

Here, we report the identification of a new E1A binding protein complex that is essential for
E1A-mediated transformation. Its core component is a SWI2/SNF2-related, 400 kDa protein (…

… Yasutake Katoh,1,2 Tsuyoshi Ikura,1,6 Yutaka Hoshikawa,3 Satoshi Tashiro,4 Takashi Ito,5
Mineto Ohta,1 Yohei Kera,1 Tetsuo Noda,3 and Kazuhiko Igarashi1,2,* … T A …

… by not only antigen but also by cytokines and cell-cell signaling emitted by T cells ( …
Genetic ablation of Bach2 in mice severely abrogates both T-cell-independent and T-cell-dependent …

The ubiquitin (Ub)-conjugating enzyme Ubc13 is implicated in Rad6/Rad18-dependent
postreplication repair (PRR) in budding yeast, but its function in vertebrates is not known. We …

A balanced deoxyribonucleotide (dNTP) supply is essential for DNA repair. Here, we found
that ribonucleotide reductase (RNR) subunits RRM1 and RRM2 accumulated very rapidly at …