Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
…, H Suzuki, N Shimada, K Chiba, T Ishizaki… - Pharmacology & …, 1997 - Elsevier
… In this review, all calculations of CL,,t,in viva for compounds with CLhs greater than half the
normal Q,, were carried out using oral data. We actually simulated the effect of changes in Qh …
normal Q,, were carried out using oral data. We actually simulated the effect of changes in Qh …
[HTML][HTML] Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion
S Narumiya, M Tanji, T Ishizaki - Cancer and Metastasis Reviews, 2009 - Springer
The Rho subgroup of the Rho GTPases consisting of RhoA, RhoB and RhoC induces a specific
type of actin cytoskeleton and carry out a variety of functions in the cell. mDia and ROCK …
type of actin cytoskeleton and carry out a variety of functions in the cell. mDia and ROCK …
Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapies
…, A Nakamura, A Hishida, T Ishizaki - Drug metabolism and …, 2005 - jstage.jst.go.jp
… 12) Sohn, DR, Kobayashi, K., Chiba, K., Lee, KH, Shin, SG, Ishizaki, T.: Disposition kinetics
and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4?-…
and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4?-…
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
…, T Ishizaki, H Satoh, T Ono, T Kawahara, T Morishita… - Nature, 1997 - nature.com
… Significant difference was evaluated by Student's unpaired t-test; * P < 0.05 and ** P < 0.01,
… [ 125 I]Y-35526 was synthesized from the parent compound by the chloramine-T method. …
… [ 125 I]Y-35526 was synthesized from the parent compound by the chloramine-T method. …
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
M Maekawa, T Ishizaki, S Boku, N Watanabe, A Fujita… - Science, 1999 - science.org
The actin cytoskeleton undergoes extensive remodeling during cell morphogenesis and
motility. The small guanosine triphosphatase Rho regulates such remodeling, but the …
motility. The small guanosine triphosphatase Rho regulates such remodeling, but the …
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent …
The transition of cell–matrix adhesions from the initial punctate focal complexes into the
mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, …
mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, …
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
N Watanabe, T Kato, A Fujita, T Ishizaki… - Nature cell …, 1999 - nature.com
The small GTPase Rho induces the formation of actin stress fibres and mediates the formation
of diverse actin structures. However, it remains unclear how Rho regulates its effectors to …
of diverse actin structures. However, it remains unclear how Rho regulates its effectors to …
[HTML][HTML] p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
N Watanabe, P Madaule, T Reid, T Ishizaki… - The EMBO …, 1997 - embopress.org
Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin
cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is a …
cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is a …
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases
T Ishizaki, M Uehata, I Tamechika, J Keel… - Molecular …, 2000 - ASPET
Y-27632 [(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride]
is widely used as a specific inhibitor of the Rho-associated coiled-coil forming protein …
is widely used as a specific inhibitor of the Rho-associated coiled-coil forming protein …
The small GTP‐binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
T Ishizaki, M Maekawa, K Fujisawa, K Okawa… - The EMBO …, 1996 - embopress.org
The small GTP‐binding protein Rho functions as a molecular switch in the formation of focal
adhesions and stress fibers, cytokinesis and transcriptional activation. The biochemical …
adhesions and stress fibers, cytokinesis and transcriptional activation. The biochemical …