Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target
The aryl hydrocarbon receptor (AHR) is highly expressed in multiple organs and tissues, and
there is increasing evidence that the AHR plays an important role in cellular homeostasis …
there is increasing evidence that the AHR plays an important role in cellular homeostasis …
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets
S Safe, UH Jin, E Hedrick, A Reeder… - Molecular …, 2014 - academic.oup.com
The nuclear orphan receptors for which endogenous ligands have not been identified include
nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X …
nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X …
Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target
SK Kolluri, UH Jin, S Safe - Archives of toxicology, 2017 - Springer
The aryl hydrocarbon receptor (AhR) was initially identified as the receptor that binds and
mediates the toxic effects induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and …
mediates the toxic effects induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and …
Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities
The tryptophan metabolites indole, indole-3-acetate, and tryptamine were identified in mouse
cecal extracts and fecal pellets by mass spectrometry. The aryl hydrocarbon receptor (AHR…
cecal extracts and fecal pellets by mass spectrometry. The aryl hydrocarbon receptor (AHR…
A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: isolation and identification from methanol …
A phenolic compound responsible for anti-MMP-9, which is known to be involved in tumor
cell invasion and metastasis, has been isolated from methanol extracts prepared from stem …
cell invasion and metastasis, has been isolated from methanol extracts prepared from stem …
[HTML][HTML] Activation of the programmed cell death pathway by inhibition of proteasome function in plants
M Kim, JW Ahn, UH Jin, D Choi, KH Paek… - Journal of Biological …, 2003 - ASBMB
Proteasomes constitute the major machinery to degrade or process proteins by ATP/ubiquitin-mediated
proteolysis. Recent findings suggest a pivotal role of the ubiquitin/proteasome …
proteolysis. Recent findings suggest a pivotal role of the ubiquitin/proteasome …
Effect of cosmetic outcome on quality of life after breast cancer surgery
Purpose Studies regarding the effects of aesthetic outcomes after breast cancer surgery on
quality of life (QoL) have yielded inconsistent results. This study analyzed the aesthetic …
quality of life (QoL) have yielded inconsistent results. This study analyzed the aesthetic …
[HTML][HTML] Minimally invasive versus conventional mitral valve surgery: a propensity-matched comparison
…, J Rajeswaran, G Krishnaswamy, U Jin… - The Journal of Thoracic …, 2010 - Elsevier
OBJECTIVE: Less invasive approaches to mitral valve surgery are increasingly used for
improved cosmesis; however, few studies have investigated their effect on outcome. We sought …
improved cosmesis; however, few studies have investigated their effect on outcome. We sought …
Nuclear receptor 4A (NR4A) family–orphans no more
S Safe, UH Jin, B Morpurgo, A Abudayyeh… - The Journal of steroid …, 2016 - Elsevier
The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …
[HTML][HTML] The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis
Background Patients with ER-negative breast tumors are among the most difficult to treat
and exhibit low survival rates due, in part, to metastasis from the breast to various distal sites. …
and exhibit low survival rates due, in part, to metastasis from the breast to various distal sites. …