Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target

S Safe, SO Lee, UH Jin - Toxicological Sciences, 2013 - academic.oup.com
The aryl hydrocarbon receptor (AHR) is highly expressed in multiple organs and tissues, and
there is increasing evidence that the AHR plays an important role in cellular homeostasis …

Minireview: role of orphan nuclear receptors in cancer and potential as drug targets

S Safe, UH Jin, E Hedrick, A Reeder… - Molecular …, 2014 - academic.oup.com
The nuclear orphan receptors for which endogenous ligands have not been identified include
nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X …

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target

SK Kolluri, UH Jin, S Safe - Archives of toxicology, 2017 - Springer
The aryl hydrocarbon receptor (AhR) was initially identified as the receptor that binds and
mediates the toxic effects induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and …

Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities

UH Jin, SO Lee, G Sridharan, K Lee, LA Davidson… - Molecular …, 2014 - ASPET
The tryptophan metabolites indole, indole-3-acetate, and tryptamine were identified in mouse
cecal extracts and fecal pellets by mass spectrometry. The aryl hydrocarbon receptor (AHR…

A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: isolation and identification from methanol …

UH Jin, JY Lee, SK Kang, JK Kim, WH Park, JG Kim… - Life sciences, 2005 - Elsevier
A phenolic compound responsible for anti-MMP-9, which is known to be involved in tumor
cell invasion and metastasis, has been isolated from methanol extracts prepared from stem …

[HTML][HTML] Activation of the programmed cell death pathway by inhibition of proteasome function in plants

M Kim, JW Ahn, UH Jin, D Choi, KH Paek… - Journal of Biological …, 2003 - ASBMB
Proteasomes constitute the major machinery to degrade or process proteins by ATP/ubiquitin-mediated
proteolysis. Recent findings suggest a pivotal role of the ubiquitin/proteasome …

Effect of cosmetic outcome on quality of life after breast cancer surgery

MK Kim, T Kim, HG Moon, US Jin, K Kim, J Kim… - European Journal of …, 2015 - Elsevier
Purpose Studies regarding the effects of aesthetic outcomes after breast cancer surgery on
quality of life (QoL) have yielded inconsistent results. This study analyzed the aesthetic …

[HTML][HTML] Minimally invasive versus conventional mitral valve surgery: a propensity-matched comparison

…, J Rajeswaran, G Krishnaswamy, U Jin… - The Journal of Thoracic …, 2010 - Elsevier
OBJECTIVE: Less invasive approaches to mitral valve surgery are increasingly used for
improved cosmesis; however, few studies have investigated their effect on outcome. We sought …

Nuclear receptor 4A (NR4A) family–orphans no more

S Safe, UH Jin, B Morpurgo, A Abudayyeh… - The Journal of steroid …, 2016 - Elsevier
The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …

[HTML][HTML] The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis

UH Jin, SO Lee, C Pfent, S Safe - BMC cancer, 2014 - Springer
Background Patients with ER-negative breast tumors are among the most difficult to treat
and exhibit low survival rates due, in part, to metastasis from the breast to various distal sites. …