User profiles for Y. A. Hannun
Yusuf A HannunDirector, Stony Brook Cancer Center Verified email at sbumed.org Cited by 92245 |
Principles of bioactive lipid signalling: lessons from sphingolipids
It has become increasingly difficult to find an area of cell biology in which lipids do not have
important, if not key, roles as signalling and regulatory molecules. The rapidly expanding …
important, if not key, roles as signalling and regulatory molecules. The rapidly expanding …
Functions of ceramide in coordinating cellular responses to stress
YA Hannun - Science, 1996 - science.org
Sphingolipid metabolites participate in key events of signal transduction and cell regulation.
In the sphingomyelin cycle, a number of extracellular agents and insults (such as tumor …
In the sphingomyelin cycle, a number of extracellular agents and insults (such as tumor …
Biologically active sphingolipids in cancer pathogenesis and treatment
B Ogretmen, YA Hannun - Nature Reviews Cancer, 2004 - nature.com
Biologically active sphingolipids have key roles in the regulation of several fundamental
biological processes that are integral to cancer pathogenesis. Recent significant progress in …
biological processes that are integral to cancer pathogenesis. Recent significant progress in …
Programmed cell death induced by ceramide
Sphingomyelin hydrolysis and ceramide generation have been implicated in a signal transduction
pathway that mediates the effects of tumor necrosis factor-α (TNF-α) and other agents …
pathway that mediates the effects of tumor necrosis factor-α (TNF-α) and other agents …
[HTML][HTML] Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.
YA Hannun, CR Loomis, AH Merrill Jr… - Journal of Biological …, 1986 - Elsevier
Sphingosine inhibited protein kinase C activity and phorbol dibutyrate binding. When the
mechanism of inhibition of activity and phorbol dibutyrate binding was investigated in vitro …
mechanism of inhibition of activity and phorbol dibutyrate binding was investigated in vitro …
Functions of sphingolipids and sphingolipid breakdown products in cellular regulation
YA Hannun, RM Bell - Science, 1989 - science.org
The discovery that breakdown products of cellular sphingolipids are biologically active has
generated interest in the role of these molecules in cell physiology and pathology. …
generated interest in the role of these molecules in cell physiology and pathology. …
Sphingolipids and their metabolism in physiology and disease
Studies of bioactive lipids in general and sphingolipids in particular have intensified over
the past several years, revealing an unprecedented and unanticipated complexity of the …
the past several years, revealing an unprecedented and unanticipated complexity of the …
[HTML][HTML] The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind
Events—The cloning of enzymes that clear ceramide such as GCS and CDases (1, 2), the
generation of knock-out mice in acid SMase (13), and the development/discovery of specific …
generation of knock-out mice in acid SMase (13), and the development/discovery of specific …
An overview of sphingolipid metabolism: from synthesis to breakdown
Sphingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol
backbones which are synthesized in the ER from nonsphingolipid precursors. Modification of …
backbones which are synthesized in the ER from nonsphingolipid precursors. Modification of …
Ceramide in apoptosis: an overview and current perspectives
BJ Pettus, CE Chalfant, YA Hannun - … (BBA)-Molecular and Cell Biology of …, 2002 - Elsevier
Recent years have witnessed significant advances in the understanding of the role of ceramide
in apoptosis. This review summarizes these recent findings and discusses insights from …
in apoptosis. This review summarizes these recent findings and discusses insights from …