The modulation of neurotransmitter receptors by various substances can reflect important
physiological mechanisms involved in the regulation of neural function. Furthermore, such …

The effects of estrogens and xenoestrogens on human neuronal nicotinic acetylcholine
receptor/channels were examined by expressing recombinant channels in Xenopus …

The major brain nicotinic acetylcholine receptor is assembled from two subunits termed
alpha 4 and n alpha 1. When expressed in Xenopus oocytes, these subunits reconstitute a …

HEK293 cells were stably transfected with rat neuronal nicotinic α4 and β2 subunits. Binding
of tritiated cytisine and nicotine to cell homogenates revealed the presence of a single class …

We have shown previously that chronic exposure to submicromolar concentrations of
nicotine permanently inactivates α4β2 and α7 neuronal nicotinic acetylcholine receptors …

Effects of agonists on rat α3β4 nicotinic acetylcholine receptors expressed in KXα3β4R2
cells [human embryonic kidney 293-derived cells] were studied. The potencies of seven …

Steroids, in addition to regulating gene expression, directly affect a variety of ion channels.
We examined the action of steroids on human embryonic kidney 293 cells stably transfected …

Effects of cholinergic drugs on human α4β2 nicotinic acetylcholine receptors expressed in
Xenopus oocytes have been investigated in electrophysiological and ligand binding …

Human nicotinic acetylcholine (ACh) receptor subtypes expressed in Xenopus oocytes were
characterized in terms of their activation by the experimental agonist RJR‐2403. Responses …

Neuronal nicotinic acetylcholine receptors are differentially sensitive to blockade by the
competitive antagonist dihydro‐β‐erythroidine. Both α and β subunits participate in …