A peroxisome proliferator-activated receptor γ-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene …

R Krätzner, F Fröhlich, K Lepler, M Schröder… - Molecular …, 2008 - ASPET
The peptide hormone glucagon stimulates hepatic glucose output, and its levels in the blood
are elevated in type 2 diabetes mellitus. The nuclear receptor peroxisome proliferator …

[HTML][HTML] Repression of glucagon gene transcription by peroxisome proliferator-activated receptor γ through inhibition of Pax6 transcriptional activity

S Schinner, C Dellas, M Schroder, CA Heinlein… - Journal of Biological …, 2002 - ASBMB
The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is involved in
glucose homeostasis and synthetic PPARγ ligands, the thiazolidinediones, a new class of …

Dual DNA-binding specificity of peroxisome-proliferator-activated receptor γ controlled by heterodimer formation with retinoid X receptor α

M OKUNO, E ARIMOTO, Y IKENOBU… - Biochemical …, 2001 - portlandpress.com
The peroxisome-proliferator-activated receptor γ (PPARγ) is a member of the steroid/thyroid
nuclear receptor superfamily of ligand-activated transcription factors. PPARγ forms a …

[HTML][HTML] Peroxisome proliferator-activated receptor (PPAR)-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the …

P Bai, SM Houten, A Huber, V Schreiber… - Journal of biological …, 2007 - ASBMB
The peroxisome proliferator-activated receptor-γ (PPARγ, NR1C3) in complex with the
retinoid X receptor (RXR) plays a central role in white adipose tissue (WAT) differentiation …

The peroxisome proliferator-activated receptor interacts with the retinoid X receptor in vivo

KS Miyata, SE McCaw, SL Marcus, RA Rachubinski… - Gene, 1994 - Elsevier
The peroxisome proliferator-activated receptor (PPAR) binds cooperatively to cognate
peroxisome proliferator-responsive elements (PPRE) in vitro through heterodimerization …

[HTML][HTML] T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities

G Lee, F Elwood, J McNally, J Weiszmann… - Journal of Biological …, 2002 - ASBMB
The nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ
(NR1C3)) plays a central role in adipogenesis and is the molecular target for the …

[HTML][HTML] In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor γ response element in the mouse pdx-1 promoter

D Gupta, TL Jetton, RM Mortensen, SZ Duan… - Journal of Biological …, 2008 - ASBMB
We reported that peroxisome proliferator-activated receptor γ (PPARγ) transcriptionally
regulates the β-cell differentiation factor pancreatic duodenal homeobox (PDX)-1 based on …

Subtype-and response element-dependent differences in transactivation by peroxisome proliferator-activated receptors α and γ

A Kassam, J Hunter, RA Rachubinski… - Molecular and cellular …, 1998 - Elsevier
Peroxisome proliferator-activated receptors (PPAR) modulate transcription by binding to
specific peroxisome proliferator-response elements (PPRE) through heterodimerization with …

[HTML][HTML] Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor γ (PPARγ): differential activity of PPARγ1 and-2 …

A Werman, A Hollenberg, G Solanes, C Bjørbæk… - Journal of Biological …, 1997 - ASBMB
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear hormone
receptor superfamily, and is an important regulator of adipogenesis and adipocyte gene …

Ligand-mediated regulation of peroxisome proliferator-activated receptor (PPAR) β/δ: a comparative analysis of PPAR-selective agonists and all-trans retinoic acid

M Rieck, W Meissner, S Ries… - Molecular …, 2008 - ASPET
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily that modulate target gene expression in response to natural fatty acid …