Supplemental Data
Files in this Data Supplement:
- Supplemental Figures -
Supplemental Fig. 1 - Elevated K+e and extracellular tetraethylammonium (TEA, 10 mM) slow the rate of T432S/A443S hEAG1 inactivation
Supplemental Fig. 2 - Comparison of simulated ICA dockings to homology models of hERG1 and hEAG1 pore modules in the open state
Supplemental Fig. 3 - Effect of ICA on mutant hEAG1 channels
Supplemental Fig. 4 - Effect of ICA on L646E hERG1 and M458E hEAG1 channel currents
Supplemental Fig. 5 - Molecular models of ICA docked to F359L hEAG1 channel
- Model of ICA docked to the open state of the hEAG pore module
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(Fig. 3A-C)
- Model of ICA docked to the open state of the hEAG pore module
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(Fig. 3D-F)
- Model of ICA docked to open state of M431F/M458L/L463M hEAG1 channel pore module
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(Fig. 6A and B)
- Model of ICA docked to closed state of M431F/M458L/L463M hEAG1 channel pore module
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(Fig. 6C and D)
- Molecular model of ICA docked to the open state of the hERG1 pore module
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(Supplemental Fig. 2A)
- Molecular model of ICA docked to open state of F359L hEAG1 channel
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(Supplemental Fig. 5A, B)
- Molecular model of ICA docked to closed state of F359L hEAG1 channel
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(Supplemental Fig. 5C, D)