Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Table S1 - Compounds screened for AHR antagonism
Figure S1 - Chemical synthesis of (E)-1-Methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1Hpyrazole- 5-carboxamide (CH223191)
Figure S2 - Structure of prototypic AHR-binding flavonoid pharmacophore
Figure S3 - CB7993113 has no effect on PPAR-gamma--dependent or CMV-driven reporter activity
Figure S4 - Titration of AHR-driven reporter activity induced by two AHR agonists, beta-NF and TCDD, in the presence of increasing concentrations of CB7993113
Figure S5 - Amino acid alignment of human HIF-2-alpha and AHR PAS-B Domain
- CID.pdb
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A model of the human AHR PAS-B domain in complex with CB7993113 together with computational solvent mapping (http://ftmap.bu.edu) of the PAS-B domain
- CID1.pdb
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A model of the human AHR PAS-B domain in complex with CB7993113