Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplementary Table 1 - Average IC50 values for inhibition of ATX lysoPLD activity
Supplementary Figure 1 - Initial Fo ? Fc map (3-omega contour, yellow) showing well defined density for both the PAT-347 (purple) and 14:0 LPA (orange) molecules
Supplementary Figure 2 - Initial Fo ? Fc map (3-omega contour, brown) showing well defined density for both the PAT-494 (salmon) and AA (yellow) molecules
Supplementary Figure 3 - Characterization of the purified, recombinant ATX doubledeglycosylation mutant (DDM) used in the crystallization process
Supplementary Figure 4 - Characterization of the four isoforms of human ATX
Supplementary Figure 5 - Inhibition of endogenous ATX
Supplementary Figure 6 - Effect of LPA on ATX activity
Supplementary Figure 7 - Effect of arachidonic acid (AA) on ATX activity
- PT-352
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4ZG9 represents the PDB deposition code for the ATX/PAT-352 crystal structure
- PT-347
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4ZG7 represents the PDB deposition code for the ATX/PAT-347 crystal structure
- PT-494
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4ZGA represents the PDB deposition code for the ATX/PAT-494 crystal structure
- PT-078
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4ZG6 represents the PDB deposition code for the ATX/PAT-078 crystal structure