Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Methods
Supplemental Figure 1 - Competitive inhibition studies
Supplementary Figure 2 - pIRE1-alpha-GSK2850163 electron density maps and binding mode
Supplementary Figure 3 - Overall structure of the human pIRE1-alpha + ADP-Mg2+ (PDB ID: 4YZD) face-to-face dimer
Supplementary Figure 4 - Electron density map and binding mode of staurosporine (STS) to pIRE1-alpha
Supplementary Figure 5 - Differential labeling in the Hydrogen/Deuterium Exchange (HDX)
Supplementary Table 1 - In vitro selectivity of GSK2850163 across a panel of 284 kinases
Preliminary Full wwPDB X-ray Structure Validation Report